Acute effect of palonosetron on electrocardiographic parameters in cancer patients: a prospective study.

Abstract

OBJECTIVES:

Palonosetron is a novel 5-hydroxytryptamine(3) (5 HT(3)) receptor antagonist, which has been shown to be superior to first generation 5 HT(3) receptor antagonists regarding the prevention of acute, delayed and overall chemotherapy-induced nausea and vomiting. First generation 5 HT(3) receptor antagonists may induce electrocardiographic changes of heart rate and repolarization. The acute cardiac effect of palonosteron is unknown. The purpose of this study is to determine acute effects of palonosetron on electrocardiographic (ECG) parameters in cancer patients.

MATERIALS AND METHODS:

The study had a prospective design. Seventy-six cancer patients with normal cardiac function who received palonosetron for prevention of chemotherapy-induced nausea and vomiting were enrolled. Standard 12-lead ECG recordings were performed at baseline and 30 min after palonosetron administration. P wave durations and corrected QT intervals were measured; P wave dispersion (Pd) and QTc dispersion were calculated.

RESULTS:

Median heart rate did not differ among 76 patients enrolled before and after palonosetron administration (p: 0.6). Systolic and diastolic blood pressures were not significantly different before and after palonosteron (p values 0.9 and 0.3, respectively). Although median QT min value was higher after palonosetron administration than before palonosetron administration, the difference was not statistically significant (p: 0.6).

CONCLUSION:

Palonosetron seems to have no acute arrhythmogenic potential.

• Authors: C Yavas, U Dogan, G Yavas, M Araz, O Yavas Ata
• Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (Support Care Cancer) Vol. 20 Issue 10 Pg. 2343-7 (Oct 2012) ISSN: 1433-7339 [Electronic] Germany
• PMID: 22170340 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Isoquinolines
• Quinuclidines
• Serotonin Antagonists
• Palonosetron

Topics

• Adolescent
• Adult
• Aged
• Antineoplastic Agents (adverse effects)
• Electrocardiography (drug effects)
• Heart Rate (drug effects)
• Humans
• Isoquinolines (pharmacology)
• Middle Aged
• Nausea (chemically induced, prevention & control)
• Neoplasms (drug therapy)
• Palonosetron
• Prospective Studies
• Quinuclidines (pharmacology)
• Serotonin Antagonists (pharmacology)
• Vomiting (chemically induced, prevention & control)
• Young Adult