Abstract | BACKGROUND: STUDY DESIGN: Interventional randomized non-placebo-controlled trial with 3 parallel groups. SETTING & PARTICIPANTS: 53 long-term hemodialysis patients in stable conditions, 18 years or older. 50 healthy age-matched individuals served as controls. INTERVENTIONS: OUTCOMES: Plasma levels of dephosphorylated-uncarboxylated MGP, uncarboxylated osteocalcin, and PIVKA-II. MEASUREMENTS: RESULTS: At baseline, hemodialysis patients had 4.5-fold higher dephosphorylated-uncarboxylated MGP and 8.4-fold higher uncarboxylated osteocalcin levels compared with controls. PIVKA-II levels were elevated in 49 hemodialysis patients. Vitamin K(2) supplementation induced a dose- and time-dependent decrease in circulating dephosphorylated-uncarboxylated MGP, uncarboxylated osteocalcin, and PIVKA-II levels. Response rates in the reduction in dephosphorylated-uncarboxylated MGP levels were 77% and 93% in the groups receiving 135 μg and 360 μg of menaquinone-7, respectively. LIMITATIONS: Small sample size. CONCLUSIONS:
|
Authors | Ralf Westenfeld, Thilo Krueger, Georg Schlieper, Ellen C M Cranenburg, Elke J Magdeleyns, Stephan Heidenreich, Stefan Holzmann, Cees Vermeer, Willi Jahnen-Dechent, Markus Ketteler, Jürgen Floege, Leon J Schurgers |
Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 59
Issue 2
Pg. 186-95
(Feb 2012)
ISSN: 1523-6838 [Electronic] United States |
PMID | 22169620
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Copyright | Copyright © 2012 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Calcium-Binding Proteins
- Extracellular Matrix Proteins
- Protein Precursors
- alpha-2-HS-Glycoprotein
- matrix Gla protein
- Osteocalcin
- Vitamin K 2
- acarboxyprothrombin
- Prothrombin
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Calcium-Binding Proteins
(blood)
- Comorbidity
- Dietary Supplements
- Disease Progression
- Dose-Response Relationship, Drug
- Extracellular Matrix Proteins
(blood)
- Female
- Humans
- Kidney Diseases
(blood, epidemiology, therapy)
- Male
- Middle Aged
- Osteocalcin
(blood)
- Prospective Studies
- Protein Precursors
(blood)
- Prothrombin
- Renal Dialysis
- Single-Blind Method
- Treatment Outcome
- Vascular Calcification
(blood, epidemiology, prevention & control)
- Vitamin K 2
(administration & dosage, therapeutic use)
- Vitamin K Deficiency
(blood, drug therapy, epidemiology)
- alpha-2-HS-Glycoprotein
(metabolism)
|