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The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms.

AuthorsRichard B Silverman
JournalJournal of medicinal chemistry (J Med Chem) Vol. 55 Issue 2 Pg. 567-75 (Jan 26 2012) ISSN: 1520-4804 [Electronic] United States
PMID22168767 (Publication Type: Lecture, Research Support, N.I.H., Extramural)
Chemical References
  • (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid
  • Anticonvulsants
  • Proline
  • 4-Aminobutyrate Transaminase
  • Vigabatrin
Topics
  • 4-Aminobutyrate Transaminase (antagonists & inhibitors)
  • Animals
  • Anticonvulsants (chemistry, pharmacology, therapeutic use)
  • Awards and Prizes
  • Cocaine-Related Disorders (drug therapy)
  • Humans
  • Infant
  • Models, Molecular
  • Molecular Structure
  • Proline (analogs & derivatives, chemistry, pharmacology, therapeutic use)
  • Rats
  • Spasms, Infantile (drug therapy)
  • Substance-Related Disorders (drug therapy)
  • United States
  • Vigabatrin (chemistry, pharmacology, therapeutic use)

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