Low-dose aspirin does not influence the clinical course of women with mild pregnancy-induced hypertension.

Abstract

The effect of low doses of aspirin on women with mild pregnancy-induced hypertension was investigated by means of a prospective, randomized, double-blind trial. Forty-seven women hospitalized at 30-36 weeks' gestation because of mild pregnancy-induced hypertension were treated by a daily dose of either 100 mg aspirin or placebo. The mean blood pressure values, rates of development of severe preeclampsia, gestational ages at delivery, newborn weights, and 5-minute Apgar scores were similar in the aspirin-treated and the placebo-treated groups. We conclude that low-dose aspirin is not curative but is essentially a preventive treatment which, in order to be effective, should be started weeks before clinical signs of preeclampsia are present.

• Authors: E Schiff, G Barkai, G Ben-Baruch, S Mashiach
• Journal: Obstetrics and gynecology (Obstet Gynecol) Vol. 76 Issue 5 Pt 1 Pg. 742-4 (Nov 1990) ISSN: 0029-7844 [Print] United States
• PMID: 2216216 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Aspirin

Topics

• Adult
• Aspirin (administration & dosage, therapeutic use)
• Double-Blind Method
• Female
• Humans
• Hypertension (drug therapy)
• Pre-Eclampsia (prevention & control)
• Pregnancy
• Pregnancy Complications, Cardiovascular (drug therapy)
• Prospective Studies