Abstract |
A woman aged 56 years of age had a community-acquired left neck abscess and internal jugular vein thrombosis with septicemia due to extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae. Even though she was treated with intravenous meropenem, the bacteremia persisted. She was complicated with multiple brain abscesses, seizure, and leucopenia. After a combination of intravenous fosfomycin and meropenem, her clinical condition became stable. Combination treatment was continued for 2 months and she recovered. In individual cases of Lemierre syndrome with brain abscess caused by ESBL-producing Enterobacteriaceae, fosfomycin combination therapy may be the alternative choice.
|
Authors | Wen-Sen Lee, Fu-Der Wang, Ying-Hua Shieh, Sing-On Teng, Tsong-Yih Ou |
Journal | Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
(J Microbiol Immunol Infect)
Vol. 45
Issue 1
Pg. 72-4
(Feb 2012)
ISSN: 1995-9133 [Electronic] England |
PMID | 22154996
(Publication Type: Case Reports, Journal Article)
|
Copyright | Copyright © 2011. Published by Elsevier B.V. |
Chemical References |
- Anti-Bacterial Agents
- Thienamycins
- Fosfomycin
- beta-Lactamases
- Meropenem
|
Topics |
- Anti-Bacterial Agents
(administration & dosage)
- Brain
(diagnostic imaging)
- Brain Abscess
(complications, drug therapy, microbiology)
- Community-Acquired Infections
(diagnosis, drug therapy, microbiology, pathology)
- Drug Therapy, Combination
(methods)
- Female
- Fosfomycin
(administration & dosage)
- Humans
- Infusions, Intravenous
- Klebsiella Infections
(diagnosis, drug therapy, microbiology, pathology)
- Klebsiella pneumoniae
(enzymology, isolation & purification)
- Lemierre Syndrome
(diagnosis, drug therapy, microbiology, pathology)
- Meropenem
- Middle Aged
- Sepsis
(diagnosis, drug therapy, microbiology, pathology)
- Thienamycins
(administration & dosage)
- Tomography, X-Ray Computed
- Treatment Outcome
- beta-Lactamases
(metabolism)
|