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Orosomucoid serum concentrations and fat depot-specific mRNA and protein expression in humans.

Abstract
Obesity is associated with chronic low-grade inflammation, which contributes to systemic metabolic irregularities and obesity-linked metabolic disorders. Orosomucoid (ORM), an acute phase reactant protein, was shown to be produced in response to metabolic and inflammatory signals in the adipose tissue of obese mice, which protects them from severe inflammation and subsequent metabolic dysfunction. In this study, we examined whether there are site-specific differences between visceral and subcutaneous adipose tissue (VAT and SAT, respectively) ORM gene and protein expression from individuals with a wide range of obesity and the relationship between expressed and circulating ORM levels and measures of adiposity, insulin resistance, and pro- and anti-inflammatory markers and adipokines. The level of circulating ORM correlated positively with BMI, body fat mass, and serum leptin. It also correlated with fasting insulin, HOMA-IR values and C-reactive protein in men. There were no site-specific differences in ORM mRNA and protein expression between VAT and SAT, nor did we find a relationship between circulating ORM levels and its mRNA expression in either fat depot. We found that ORM mRNA expression correlated with mRNA expression of TNF-α, IL-6, and adiponectin in VAT, and with TNF-α and adiponectin in SAT. These observations are the first description linking adipose tissue ORM and pro- and anti-inflammatory molecules in humans. The close links of ORM and measures of adiposity, insulin resistance, and adipose tissue inflammation in humans reinforce previous experimental data and warrant further studies to explore a possible role of ORM in the pathogenesis of obesity-associated metabolic derangements.
AuthorsAssim A Alfadda, Sumbul Fatma, M Azhar Chishti, Mohammed Y Al-Naami, Ruba Elawad, Carmen Deanna O Mendoza, Hyunsun Jo, Yun Sok Lee
JournalMolecules and cells (Mol Cells) Vol. 33 Issue 1 Pg. 35-41 (Jan 2012) ISSN: 0219-1032 [Electronic] Korea (South)
PMID22134720 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adiponectin
  • Interleukin-6
  • Leptin
  • Orosomucoid
  • RNA, Messenger
  • Tumor Necrosis Factor-alpha
  • C-Reactive Protein
Topics
  • Adiponectin (biosynthesis, blood)
  • Adolescent
  • Adult
  • Aged
  • Animals
  • C-Reactive Protein (metabolism)
  • Female
  • Humans
  • Interleukin-6 (biosynthesis)
  • Leptin (blood)
  • Male
  • Mice
  • Middle Aged
  • Obesity (blood, genetics, metabolism)
  • Orosomucoid (biosynthesis, genetics, metabolism)
  • RNA, Messenger (genetics, metabolism)
  • Subcutaneous Fat (metabolism)
  • Tumor Necrosis Factor-alpha (biosynthesis)
  • Young Adult

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