Retrobulbar hemodynamic effects of nipradilol in normal and normal-tension glaucoma eyes.

Abstract

Purpose. To investigate the effects of nipradilol on retrobulbar hemodynamics. Methods. We investigated normal and normal-tension glaucoma (NTG) eyes. Topical nipradilol (one eye) and placebo eye drops (fellow eye) were instilled for 1 week in volunteers. Nipradilol was also instilled in NTG patients. Ultrasound color Doppler imaging for the posterior vessels was performed before, 2 hr, 1 week (for normal), and at 4 weeks (for NTG). Results. In normal eyes, there were significant decreases in the resistance index (RI) for the temporal short posterior ciliary arteries (PCA) at 2 hr and for the ophthalmic arteries at 1 week. There were no significant changes in the placebo-treated eyes. In the NTG eyes, there was a significant decrease in the RI for the central retinal artery, nasal, and temporal PCA at 2 hr and 4 weeks. Conclusion. Short-term observations found that nipradilol increased the ocular blood flow in normal and NTG eyes.

• Authors: Mitsushi Fukukita, Masashi Ido, Syunsuke Osawa, Mikio Sasoh, Motoyasu Furuta, Kunio Ito, Masahiko Sugimoto, Yukitaka Uji
• Journal: Journal of ophthalmology (J Ophthalmol) Vol. 2011 Pg. 652904 ( 2011) ISSN: 2090-0058 [Electronic] United States
• PMID: 22132312 (Publication Type: Journal Article)