Abstract | BACKGROUND: OBJECTIVE: This study was carried out to investigate the potential antifibrotic effect of Protocatechuic aldehyde (PA) on experimental liver fibrosis in vitro and in vivo, and to explore its possible mechanism. MATERIALS AND METHODS: RESULTS: Overall, our results indicated that PA inhibits HSCs proliferation, inhibits the levels of TGF-β1, CTGF, type I collagen and type III collagen in TNF-α stimulated HSCs. Treatment of PA causes a significant reduction in fibrosis grade, ameliorates biochemical indicators and histopathological morphology, and reduces liver TGF-β1 and CTGF expression in rat model of CCL(4)-induced liver fibrosis. CONCLUSION: These findings suggest that PA has potentially conferring antifibrogenic effects.
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Authors | Chunmei Li, Wanglin Jiang, Haibo Zhu, Jian Hou |
Journal | Pharmaceutical biology
(Pharm Biol)
Vol. 50
Issue 4
Pg. 413-9
(Apr 2012)
ISSN: 1744-5116 [Electronic] England |
PMID | 22129045
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Retracted Publication)
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Chemical References |
- Benzaldehydes
- CCN2 protein, rat
- Catechols
- Collagen Type I
- Collagen Type III
- Laminin
- Protective Agents
- Tgfb1 protein, rat
- Transforming Growth Factor beta1
- Tumor Necrosis Factor-alpha
- Connective Tissue Growth Factor
- protocatechualdehyde
- Hyaluronic Acid
- Carbon Tetrachloride
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Topics |
- Animals
- Benzaldehydes
(pharmacology)
- Blotting, Western
- Carbon Tetrachloride
- Catechols
(pharmacology)
- Cell Proliferation
(drug effects)
- Cells, Cultured
- Collagen Type I
(metabolism)
- Collagen Type III
(metabolism)
- Connective Tissue Growth Factor
(metabolism)
- Cytoprotection
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Enzyme-Linked Immunosorbent Assay
- Hepatic Stellate Cells
(drug effects, metabolism, pathology)
- Hyaluronic Acid
(metabolism)
- Immunohistochemistry
- Laminin
(metabolism)
- Liver
(drug effects, metabolism, pathology)
- Liver Cirrhosis
(chemically induced, metabolism, pathology, prevention & control)
- Male
- Protective Agents
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Transforming Growth Factor beta1
(metabolism)
- Tumor Necrosis Factor-alpha
(metabolism)
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