Abstract | OBJECTIVE: METHODS: MRIs were evaluated according to the Berlin sacroiliac (SI) joint and spine inflammation scoring method at baseline, week 22, and week 46. Radiographs were evaluated using the modified Stoke Ankylosing Spondylitis Spine Score at baseline and week 46. Patients with new syndesmophytes were identified. Biomarker levels in patients were compared to levels in healthy subjects. RESULTS: Higher pretreatment MRI inflammation scores for SI joints and/or lumbar spine were associated with higher baseline CTX-II levels, but not with higher levels of biomarkers of inflammation and bone turnover. During treatment with TNFα inhibitors, a decrease in MRI inflammation scores from baseline to week 22 was associated with larger percentage decreases in and a normalization of CRP and IL-6 levels as compared to an increase or no change in MRI scores. Development of new syndesmophytes was associated with larger percentage decreases in CRP and IL-6 levels and an increase in osteocalcin level, and with normalization of CRP and IL-6 levels from baseline to week 22. Persistent systemic inflammation was associated with radiographic nonprogression. CONCLUSION: Our findings indicate that inflammation on baseline MRI is associated with higher CTX-II levels. Radiographic progression is associated with decreased systemic inflammation, as assessed by IL-6 and CRP levels and MRI, supporting the notion of a link between the resolution of inflammation and new bone formation in SpA patients during anti-TNFα therapy.
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Authors | Susanne Juhl Pedersen, Inge Juul Sørensen, Robert G W Lambert, Kay-Geert A Hermann, Patrick Garnero, Julia Sidenius Johansen, Ole Rintek Madsen, Annette Hansen, Michael Sejer Hansen, Gorm Thamsborg, Lis Smedegaard Andersen, Ole Majgaard, Anne Gitte Loft, Jon Erlendsson, Karsten H Asmussen, Anne Grethe Jurik, Jakob Møller, Maria Hasselquist, Dorrit Mikkelsen, Mikkel Østergaard |
Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 63
Issue 12
Pg. 3789-800
(Dec 2011)
ISSN: 1529-0131 [Electronic] United States |
PMID | 22127697
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 by the American College of Rheumatology. |
Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Biomarkers
- Cartilage Oligomeric Matrix Protein
- Extracellular Matrix Proteins
- Glycoproteins
- Interleukin-6
- Matrilin Proteins
- TSP5 protein, human
- Tumor Necrosis Factor-alpha
- Vascular Endothelial Growth Factor A
- Osteocalcin
- C-Reactive Protein
- Infliximab
- Matrix Metalloproteinase 3
- Adalimumab
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Topics |
- Adalimumab
- Adult
- Antibodies, Monoclonal
(therapeutic use)
- Antibodies, Monoclonal, Humanized
(therapeutic use)
- Biomarkers
(blood)
- Bone and Bones
(metabolism)
- C-Reactive Protein
(metabolism)
- Cartilage
(metabolism)
- Cartilage Oligomeric Matrix Protein
- Case-Control Studies
- Cohort Studies
- Disease Progression
- Extracellular Matrix Proteins
(blood)
- Female
- Glycoproteins
(blood)
- Humans
- Inflammation
(diagnostic imaging, pathology)
- Infliximab
- Interleukin-6
(blood)
- Magnetic Resonance Imaging
- Male
- Matrilin Proteins
- Matrix Metalloproteinase 3
(blood)
- Middle Aged
- Neovascularization, Pathologic
(blood)
- Osteocalcin
(blood)
- Prospective Studies
- Radiography
- Spondylarthritis
(blood, drug therapy)
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
- Vascular Endothelial Growth Factor A
(blood)
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