Abstract | BACKGROUND: METHODS: 40 women with GDM of term pregnancy were recruited and 40 maternal age- and gestational age-matched normally pregnant women served as control. Maternal blood samples and placental tissues were collected. Maternal concentrations of FSTL3 and myostatin were determined by enzyme-linked immunosorbent assay (ELISA), and, placental concentrations of FSTL3 by Western blotting. RESULTS: Women with GDM had significantly lower serum FSTL3 concentrations than controls (P=0.001). Placental concentrations of FSTL3 were significantly lower in GDM group than in controls (P<0.001). Women with GDM had significantly higher homeostasis model assessment of insulin resistance (HOMA-IR) and glycosylated hemoglobin (HbAlc) than control women (P=0.042 and <0.01, respectively). Maternal serum myostatin was not significantly different between GDM and control groups (P=0.312). CONCLUSIONS: Maternal and placental FSTL3 concentrations were reduced in GDM women compared with normally pregnant women, suggesting FSTL3 may play an important role in the pathogenesis of gestational diabetes.
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Authors | Dongxiao Hu, Ting Tian, Jing Guo, Hanzhi Wang, Danqing Chen, Minyue Dong |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 413
Issue 5-6
Pg. 533-6
(Mar 22 2012)
ISSN: 1873-3492 [Electronic] Netherlands |
PMID | 22122995
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier B.V. All rights reserved. |
Chemical References |
- Follistatin-Related Proteins
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Topics |
- Adult
- Case-Control Studies
- Diabetes, Gestational
(blood, metabolism)
- Female
- Follistatin-Related Proteins
(analysis, blood)
- Humans
- Placenta
(metabolism)
- Pregnancy
- Pregnancy Complications
(blood, metabolism)
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