Abstract | BACKGROUND/OBJECTIVES: METHODS: Sixty-four patients with proximal/mid segment of the LAD lesions and 51 patients with distal segments of the LAD lesions were included in this study. Soluble LOX-1 levels were measured in all study subjects. RESULTS: Baseline characteristics of the two groups were similar. In stable CAD, patients with proximal/middle segment of the LAD lesions had significantly higher circulating soluble LOX-1 levels than patients with distal segments of the LAD lesions (1.07 ± 0.33 vs. 0.70 ± 0.17 ng/ml, p < 0.001). No correlation was found between plasma-soluble LOX-1 levels and fasting glucose, lipid profile. For predicting proximal/middle LAD lesions, the highest specificity (95,2%) and sensitivity (53,8%) levels were obtained at the cut-off value of 0.68. CONCLUSION: Our study demonstrated that serum-soluble LOX-1 levels were associated with proximal/mid segment of the LAD lesions. Furthermore, this study suggested soluble LOX-1 might be a useful biomarker of coronary plaque vulnerability in patients with stable CAD. Soluble LOX-1, the novel biochemical marker, may provide new insights into not only risk stratification but also therapeutic strategy for CAD.
|
Authors | Mehmet Balın, Ahmet Celik, M Ali Kobat |
Journal | Clinical research in cardiology : official journal of the German Cardiac Society
(Clin Res Cardiol)
Vol. 101
Issue 4
Pg. 247-53
(Apr 2012)
ISSN: 1861-0692 [Electronic] Germany |
PMID | 22116101
(Publication Type: Journal Article)
|
Chemical References |
- Biomarkers
- Lipids
- OLR1 protein, human
- Scavenger Receptors, Class E
- Glucose
|
Topics |
- Aged
- Biomarkers
(metabolism)
- Coronary Artery Disease
(physiopathology)
- Female
- Glucose
(metabolism)
- Humans
- Lipids
(blood)
- Male
- Middle Aged
- Plaque, Atherosclerotic
(pathology)
- Prospective Studies
- Scavenger Receptors, Class E
(metabolism)
- Sensitivity and Specificity
|