HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Zoledronic acid in the treatment of early-stage breast cancer: is there a final verdict?

Abstract
Breast cancer, which preferentially metastasizes to bone, is the most common malignancy among women worldwide and is a leading cause of death. Clinical data from large, phase 3 trials (ie, ABCSG-12, ZO-FAST, and AZURE) demonstrate significantly improved disease-free survival with zoledronic acid in some patient populations with early breast cancer. Although the interim results from the AZURE trial did not show a disease-free survival benefit with zoledronic acid in the overall patient population, subset analyses showed that zoledronic acid significantly improved disease-free survival in women with established postmenopausal status at baseline. Similarly, subset analyses of the ABCSG-12 trial showed greater benefits from zoledronic acid in patients over 40 years of age who theoretically would have achieved more complete ovarian suppression. Together, these data support a potential role for zoledronic acid beyond bone health in breast cancer and suggest that the endocrine environment may influence the anticancer potential of zoledronic acid.
AuthorsMichael Gnant
JournalCurrent oncology reports (Curr Oncol Rep) Vol. 14 Issue 1 Pg. 35-43 (Feb 2012) ISSN: 1534-6269 [Electronic] United States
PMID22113793 (Publication Type: Journal Article, Review)
Chemical References
  • Antineoplastic Agents, Hormonal
  • Bone Density Conservation Agents
  • Diphosphonates
  • Imidazoles
  • Zoledronic Acid
Topics
  • Antineoplastic Agents, Hormonal (therapeutic use)
  • Bone Density Conservation Agents (therapeutic use)
  • Breast Neoplasms (drug therapy, mortality, pathology)
  • Chemotherapy, Adjuvant
  • Clinical Trials as Topic
  • Diphosphonates (therapeutic use)
  • Disease-Free Survival
  • Female
  • Humans
  • Imidazoles (therapeutic use)
  • Survival Rate
  • Zoledronic Acid

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: