Long-term effect of acetazolamide in a patient with retinitis pigmentosa.

Abstract

The authors studied the therapeutic effect of acetazolamide on a patient with autosomal dominant retinitis pigmentosa complicated by retinal edema. In addition to reduction of macular edema and some improvement of central vision, they found an unexpected progressive increase in extrafoveal retinal sensitivity with prolonged medication. It is proposed that the therapeutic effect is mediated by alteration of retinal pigment epithelial function and that disturbed polarity is restored to a more normal state.

• Authors: J C Chen, F W Fitzke, A C Bird
• Journal: Investigative ophthalmology & visual science (Invest Ophthalmol Vis Sci) Vol. 31 Issue 9 Pg. 1914-8 (Sep 1990) ISSN: 0146-0404 [Print] United States
• PMID: 2211037 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acetazolamide

Topics

• Acetazolamide (therapeutic use)
• Female
• Humans
• Longitudinal Studies
• Macular Edema (drug therapy, etiology)
• Middle Aged
• Psychophysics
• Retina (drug effects)
• Retinitis Pigmentosa (complications, drug therapy)
• Visual Acuity (drug effects)
• Visual Field Tests
• Visual Fields (drug effects)