Clinical experience with chemoradiotherapy comprising S-1 plus low-dose cisplatin in a patient with stage IV anal cancer.
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| Abstract |
We report a case of anal cancer in a 58-year-old woman who complained of narrow, bloody stools and anal pain. Physical examination revealed anal stenosis associated with a circular mass arising in the anal canal. Histological examination of biopsy specimens confirmed a diagnosis of moderately differentiated squamous cell carcinoma. Enhanced computed tomography revealed anal cancer invading the levator ani and the vagina, with lymph-node, multiple hepatic, and pulmonary metastases. The patient received two cycle of chemoradiotherapy with S-1 plus low-dose cisplatin with rest for 4 weeks, leading to complete response of the primary lesion and a partial response of the metastatic lesions. Each cycle included oral S-1 (120 mg/body; day 1-21), cisplatin (10 mg/body; day 1-5, 8-12) and radiotherapy (2 Gy/day; day 1-5, 8-12, 15-19). Adverse effects of treatment were mild perineal skin erosion and mild appetite loss, but no hematologic toxicity. Although the patient died 16 months after first admission, chemoradiotherapy with S-1 plus cisplatin is potentially effective for the management of advanced anal cancer.
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| Authors | Nobuhiro Nitori, Yutaro Kato, Ayu Kato, Tomoaki Deguchi, Akihiro Okada, Masayuki Kojima, Junko Kuroda, Tomohisa Kadomura, Keisuke Kubota, Nobuto Origuchi, Masato Fujisaki, Masaki Kitajima |
| Journal | Anticancer research (Anticancer Res) Vol. 31 Issue 11 Pg. 3983-9 (Nov 2011) ISSN: 1791-7530 [Electronic] Greece |
| PMID | 22110231 (Publication Type: Case Reports, Journal Article) |
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