HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Tolvaptan for the treatment of hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion.

Abstract
Hyponatremia is prevalent in hospitalized patients and predicts a poor prognosis. The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is perceived as one of the most frequent causes of hyponatremia. Traditionally, chronic hyponatremia has been treated with fluid restriction and demeclocycline. However, these treatment options have been unsatisfactory due to problems with treatment compliance and/or safety concerns. In recent years, several vasopressin-receptor antagonists, the vaptans, were introduced into clinical practice. One of these vaptans - tolvaptan - is an oral vasopressin V2-receptor antagonist that induces free water excretion without increasing sodium excretion. Few studies have assessed the role of vaptans in treating hyponatremia in a population with only SIADH. Current data shows that vaptans may safely correct mild or moderate hyponatremia in patients with SIADH. However, further clinical trials are needed to determine the optimal dosing, proper monitoring and adequate precautions for the use of vaptans in this patient population.
AuthorsLuna Gargani, Philip H Schmidt, Mihai Gheorghiade
JournalExpert review of cardiovascular therapy (Expert Rev Cardiovasc Ther) Vol. 9 Issue 12 Pg. 1505-13 (Dec 2011) ISSN: 1744-8344 [Electronic] England
PMID22103869 (Publication Type: Journal Article, Review)
Chemical References
  • Antidiuretic Hormone Receptor Antagonists
  • Benzazepines
  • Hormone Antagonists
  • Tolvaptan
Topics
  • Animals
  • Antidiuretic Hormone Receptor Antagonists
  • Benzazepines (adverse effects, therapeutic use)
  • Hormone Antagonists (adverse effects, therapeutic use)
  • Humans
  • Hyponatremia (drug therapy, etiology)
  • Inappropriate ADH Syndrome (etiology, physiopathology)
  • Severity of Illness Index
  • Tolvaptan

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: