Abstract | BACKGROUND: OBJECTIVE: To identify the optimal gel formulation by evaluating the antipsoriatic effect in a psoriasis plaque test model. METHOD: The use of a psoriasis plaque test enables investigation of the antipsoriatic effect of several formulations and compounds in a limited number of patients, and is a useful method for predicting treatment efficacy in psoriasis vulgaris. Five different gel vehicles were investigated in two plaque test studies. RESULTS AND CONCLUSION: The optimised two-compound gels showed superior antipsoriatic effect over marketed betamethasone dipropionate solution. The results suggest that use of the psoriasis plaque test early in the development process can improve the development of topical formulations for dermatological use and can be a beneficial tool for selecting the most promising formulations for further clinical studies in psoriasis vulgaris.
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Authors | Catherine Queille-Roussel, Vibeke Hoffmann, Anders Enevold, Cecilia Ganslandt |
Journal | The Journal of dermatological treatment
(J Dermatolog Treat)
Vol. 24
Issue 4
Pg. 250-4
(Aug 2013)
ISSN: 1471-1753 [Electronic] England |
PMID | 22103604
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Dermatologic Agents
- Drug Combinations
- Gels
- Ointments
- calcipotriene
- betamethasone-17,21-dipropionate
- Betamethasone
- Calcitriol
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Topics |
- Anti-Inflammatory Agents
(chemistry, therapeutic use)
- Betamethasone
(analogs & derivatives, chemistry, therapeutic use)
- Calcitriol
(analogs & derivatives, chemistry, therapeutic use)
- Chemistry, Pharmaceutical
- Dermatologic Agents
(chemistry, therapeutic use)
- Drug Combinations
- Drug Compounding
- Female
- Gels
- Humans
- Male
- Ointments
(therapeutic use)
- Psoriasis
(diagnosis, drug therapy)
- Scalp
- Treatment Outcome
- Young Adult
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