Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Macrothelypteris torresiana is traditionally used in Chinese folk medicine for the treatment of edema for patients suffering from kidney/bladder problems due to its satisfactory therapeutic effectiveness.

AIM OF THE STUDY:

The aim of this study was to investigate the renoprotective nature of the total polyphenols fraction from Macrothelypteris torresiana (PMT).

MATERIALS AND METHODS:

The biochemical criterions of plasma and kidney tissues were evaluated to study the effects of PMT on puromycin aminonucleoside-induced chronic nephrotic syndrome (NS) in hyperlipidemic mice.

RESULTS:

In this study, the NS and hyperlipidemia were ameliorated after 9 weeks administration of PMT. Besides, PMT was able to modulate the level of renal oxidative stress and vascular endothelial growth factor-nitric oxide (VEGF-NO) pathway.

CONCLUSIONS:

It represented a potential resource of PMT for the treatment of NS involved in metabolic syndrome.

• Authors: Jinglou Chen, Yongfang Lei, Guanghua Wu, Yonghui Zhang, Wei Fu, Chaomei Xiong, Jinlan Ruan
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 139 Issue 1 Pg. 207-13 (Jan 06 2012) ISSN: 1872-7573 [Electronic] Ireland
• PMID: 22101083 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Blood Glucose
• Drugs, Chinese Herbal
• Lipids
• Polyphenols
• Protective Agents
• Vascular Endothelial Growth Factor A
• vascular endothelial growth factor A, mouse
• Nitric Oxide
• Puromycin Aminonucleoside
• Creatinine
• Nitric Oxide Synthase Type II
• Nos2 protein, mouse
• Potassium Dichromate

Topics

• Animals
• Blood Glucose (analysis)
• Blood Urea Nitrogen
• Creatinine (blood)
• Diet, High-Fat
• Disease Models, Animal
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Ferns
• Hyperlipidemias (drug therapy, etiology, metabolism)
• Kidney (drug effects, metabolism)
• Lipid Peroxidation (drug effects)
• Lipids (blood)
• Male
• Mice
• Nephrotic Syndrome (chemically induced, drug therapy, metabolism)
• Nitric Oxide (blood)
• Nitric Oxide Synthase Type II (blood)
• Oxidative Stress (drug effects)
• Phytotherapy
• Polyphenols (pharmacology, therapeutic use)
• Potassium Dichromate
• Protective Agents (pharmacology, therapeutic use)
• Puromycin Aminonucleoside
• Vascular Endothelial Growth Factor A (blood, metabolism)