Human insulin-receptor gene. Partial sequence and amplification of exons by polymerase chain reaction.

The partial sequence of the human insulin-receptor (hINSR) gene is presented. Using the gene sequence as a guide, we selected pairs of oligonucleotide primers from sites in the introns that flank each exon. These primers allowed each of the 22 exons of the hINSR gene to be amplified in vitro by the polymerase chain reaction. The sequences of the gene and oligonucleotide primers will facilitate studies of genetic variation in the hINSR gene and thereby increase our understanding of the role of this gene in the development of insulin-resistant states and glucose intolerance.
AuthorsS Seino, M Seino, G I Bell
JournalDiabetes (Diabetes) Vol. 39 Issue 1 Pg. 123-8 (Jan 1990) ISSN: 0012-1797 [Print] UNITED STATES
PMID2210055 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Amino Acids
  • Nucleotides
  • DNA
  • Receptor, Insulin
  • Amino Acid Sequence
  • Amino Acids (analysis)
  • Base Sequence
  • DNA (analysis, genetics)
  • Exons
  • Gene Amplification
  • Humans
  • Molecular Sequence Data
  • Nucleotides (analysis)
  • Polymerase Chain Reaction
  • Receptor, Insulin (analysis, genetics)

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