Abstract | OBJECTIVE: METHODS: The APP/PS1 double transgenic mouse model was used. Mice were randomly divided into five groups, i. e., the model control group, the positive control group ( Aricept), high-, middle-, and low-dose HLJDT group (at the daily dose of 865 mg*kg(-1), 433 mg*kg(-1), and 216 mg*kg(-1), respectively). Corresponding medication was daily given by gastrogavage. Seven months later superoxide dismutase (SOD) and malondialdehyde (MDA) were detected at the ten-month old mice, thus observing the effects on the morphology of CA1 hippocampal neurons and the senile plaques (SP). RESULTS:
HLJDT and Aricept could obviously increase the SOD contents and lower the MDA contents (P<0.05), attenuate the destroy of neurocytes and the formation of SP, effectively hinder the degeneration of hippocampal neurons. Better results were obtained in the middle-dose HLJDT group than in the positive control group (P<0.05). CONCLUSION: The mechanism of HLJDT in treating AD might be possibly correlated with improving anti-oxygenation, protecting hippocampal neurocytes, and reducing the formation of SP.
|
Authors | Xin Qiu, Guo-hua Chen, Tao Wang |
Journal | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
(Zhongguo Zhong Xi Yi Jie He Za Zhi)
Vol. 31
Issue 10
Pg. 1379-82
(Oct 2011)
ISSN: 1003-5370 [Print] China |
PMID | 22097209
(Publication Type: English Abstract, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
|
Chemical References |
- Drugs, Chinese Herbal
- Free Radicals
- huanglian
|
Topics |
- Alzheimer Disease
(metabolism, pathology)
- Animals
- Drugs, Chinese Herbal
(pharmacology)
- Free Radicals
(metabolism)
- Hippocampus
(drug effects, pathology)
- Male
- Mice
- Mice, Transgenic
|