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[Effects of huanglian jiedu decoction on free radicals metabolism and pathomorphism of the hippocampus in App/PS1 double transgenic mice].

AbstractOBJECTIVE:
To observe the effects of Huanglian Jiedu Decoction (HLJDT) on the metabolism of free radicals, the morphology and histopathology of hippocampal CA1 neurons in PS1/APP double transgenic mice of Alzheimer's disease (AD), and to study its possible mechanisms, thus providing experimental evidence for treating AD by HLJDT.
METHODS:
The APP/PS1 double transgenic mouse model was used. Mice were randomly divided into five groups, i. e., the model control group, the positive control group (Aricept), high-, middle-, and low-dose HLJDT group (at the daily dose of 865 mg*kg(-1), 433 mg*kg(-1), and 216 mg*kg(-1), respectively). Corresponding medication was daily given by gastrogavage. Seven months later superoxide dismutase (SOD) and malondialdehyde (MDA) were detected at the ten-month old mice, thus observing the effects on the morphology of CA1 hippocampal neurons and the senile plaques (SP).
RESULTS:
HLJDT and Aricept could obviously increase the SOD contents and lower the MDA contents (P<0.05), attenuate the destroy of neurocytes and the formation of SP, effectively hinder the degeneration of hippocampal neurons. Better results were obtained in the middle-dose HLJDT group than in the positive control group (P<0.05).
CONCLUSION:
The mechanism of HLJDT in treating AD might be possibly correlated with improving anti-oxygenation, protecting hippocampal neurocytes, and reducing the formation of SP.
AuthorsXin Qiu, Guo-hua Chen, Tao Wang
JournalZhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 31 Issue 10 Pg. 1379-82 (Oct 2011) ISSN: 1003-5370 [Print] China
PMID22097209 (Publication Type: English Abstract, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Drugs, Chinese Herbal
  • Free Radicals
  • huanglian
Topics
  • Alzheimer Disease (metabolism, pathology)
  • Animals
  • Drugs, Chinese Herbal (pharmacology)
  • Free Radicals (metabolism)
  • Hippocampus (drug effects, pathology)
  • Male
  • Mice
  • Mice, Transgenic

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