Abstract | AIMS: METHODS AND RESULTS: Fifty-three primary breast adenocarcinomas were analysed for immunohistochemical expression of calretinin. CK5/6 and epidermal growth factor receptor (EGFR) immunostaining were performed on the calretinin-positive subset. Tumours were classified as basal-like if they met standard morphological and immunohistochemical criteria. Fifteen per cent (8/53) of the breast tumours were positive for calretinin. Eighty-eight per cent (7/8) of the calretinin-positive tumours were grade 3, as compared with 20% (9/45) of the calretinin-negative tumours (P<0.001). Only 13% (1/8) of the calretinin-positive tumours were also oestrogen receptor (ER)-positive, as compared with 87% (39/45) of the calretinin-negative tumours (P<0.001). Eleven per cent (6/53) of the tumours were classified as basal-like. Of these, four were positive for calretinin and two were negative (P=0.003). CONCLUSIONS:
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Authors | George Powell, Heather Roche, William R Roche |
Journal | Histopathology
(Histopathology)
Vol. 59
Issue 5
Pg. 950-6
(Nov 2011)
ISSN: 1365-2559 [Electronic] England |
PMID | 22092406
(Publication Type: Journal Article)
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Copyright | © 2011 Blackwell Publishing Limited. |
Chemical References |
- Biomarkers, Tumor
- CALB2 protein, human
- Calbindin 2
- S100 Calcium Binding Protein G
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Topics |
- Adenocarcinoma
(diagnosis, metabolism)
- Biomarkers, Tumor
(analysis)
- Breast Neoplasms
(diagnosis, metabolism)
- Calbindin 2
- Diagnosis, Differential
- Female
- Humans
- Immunohistochemistry
- Mesothelioma
(diagnosis, metabolism)
- Neoplasm Grading
- S100 Calcium Binding Protein G
(analysis, biosynthesis)
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