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Cryoglobulinemia with acronecrosis not associated with hepatitis C infection: a case report.

Abstract
Cryoglobulinemia is a rare disease characterized by the production of monoclonal or polyclonal immunoglobulins that precipitate in cold temperature. While this phenomenon can be observed in a large number of disorders, it has been associated with hepatitis C virus infection in more than 90% of cases. The remaining 10%, called essential cryoglobulinemia, has been characterized by a more severe course and a failure to respond to conventional treatment. This article describes the case of a patient with essential cryoglobulinemia presenting with acronecrosis with a poor outcome, despite treatment, leading to amputation.
AuthorsMarco A Ramírez Huaranga, Claudia C Ramos Rodríguez, David Bellido Pastrana
JournalReumatologia clinica (Reumatol Clin) 2012 Mar-Apr Vol. 8 Issue 2 Pg. 84-6 ISSN: 1885-1398 [Electronic] Spain
PMID22089061 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2011 Elsevier España, S.L. All rights reserved.
Chemical References
  • Adrenal Cortex Hormones
  • Antibodies, Monoclonal, Murine-Derived
  • Immunosuppressive Agents
  • Vasodilator Agents
  • Rituximab
  • Cyclophosphamide
  • Methylprednisolone
Topics
  • Adrenal Cortex Hormones (administration & dosage, therapeutic use)
  • Amputation, Surgical
  • Antibodies, Monoclonal, Murine-Derived (therapeutic use)
  • Combined Modality Therapy
  • Cryoglobulinemia (complications, drug therapy, pathology, surgery, therapy)
  • Cyclophosphamide (administration & dosage, therapeutic use)
  • Diabetes Mellitus, Type 2 (complications)
  • Drug Resistance
  • Drug Therapy, Combination
  • Female
  • Hepatitis C
  • Humans
  • Hypertension (complications)
  • Immunosuppressive Agents (administration & dosage, therapeutic use)
  • Ischemia (drug therapy, etiology, surgery)
  • Methylprednisolone (administration & dosage, therapeutic use)
  • Middle Aged
  • Necrosis
  • Paresthesia (drug therapy, etiology)
  • Plasmapheresis
  • Raynaud Disease (etiology)
  • Rituximab
  • Toes (blood supply, pathology, surgery)
  • Vasodilator Agents (administration & dosage, therapeutic use)

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