Abstract |
Cryoglobulinemia is a rare disease characterized by the production of monoclonal or polyclonal immunoglobulins that precipitate in cold temperature. While this phenomenon can be observed in a large number of disorders, it has been associated with hepatitis C virus infection in more than 90% of cases. The remaining 10%, called essential cryoglobulinemia, has been characterized by a more severe course and a failure to respond to conventional treatment. This article describes the case of a patient with essential cryoglobulinemia presenting with acronecrosis with a poor outcome, despite treatment, leading to amputation.
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Authors | Marco A Ramírez Huaranga, Claudia C Ramos Rodríguez, David Bellido Pastrana |
Journal | Reumatologia clinica
(Reumatol Clin)
2012 Mar-Apr
Vol. 8
Issue 2
Pg. 84-6
ISSN: 1885-1398 [Electronic] Spain |
PMID | 22089061
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2011 Elsevier España, S.L. All rights reserved. |
Chemical References |
- Adrenal Cortex Hormones
- Antibodies, Monoclonal, Murine-Derived
- Immunosuppressive Agents
- Vasodilator Agents
- Rituximab
- Cyclophosphamide
- Methylprednisolone
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Topics |
- Adrenal Cortex Hormones
(administration & dosage, therapeutic use)
- Amputation, Surgical
- Antibodies, Monoclonal, Murine-Derived
(therapeutic use)
- Combined Modality Therapy
- Cryoglobulinemia
(complications, drug therapy, pathology, surgery, therapy)
- Cyclophosphamide
(administration & dosage, therapeutic use)
- Diabetes Mellitus, Type 2
(complications)
- Drug Resistance
- Drug Therapy, Combination
- Female
- Hepatitis C
- Humans
- Hypertension
(complications)
- Immunosuppressive Agents
(administration & dosage, therapeutic use)
- Ischemia
(drug therapy, etiology, surgery)
- Methylprednisolone
(administration & dosage, therapeutic use)
- Middle Aged
- Necrosis
- Paresthesia
(drug therapy, etiology)
- Plasmapheresis
- Raynaud Disease
(etiology)
- Rituximab
- Toes
(blood supply, pathology, surgery)
- Vasodilator Agents
(administration & dosage, therapeutic use)
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