Antinociceptive and anti-inflammatory effects of olive oil (Olea europeae L.) in mice.

Abstract

CONTEXT:

Olive [Olea europaea L. (Oleaceae)] is a long-lived evergreen tree that is widespread in different parts of the world.

OBJECTIVE:

Olive oil has been reported to relieve pain; however, there is still insufficient data in the literature on the subject. Thus, it is considered worthwhile investigating the antinociceptive and anti-inflammatory effects of olive oil in adult male Balb/C mice.

MATERIALS AND METHODS:

The antinociceptive effects were studied using formalin, hot plate and writhing tests. The acute anti-inflammatory effects of olive oil in mice were studied using xylene ear edema test. Olive oil (1, 5 and 10 ml/kg body wt.) was injected intraperitoneally. Intact animals served as controls.

RESULTS:

Our results showed that the olive oil only decreased the second phase of formalin-induced pain. In the hot plate test, olive oil did not raise the pain threshold over the 60 min duration of the test. Olive oil exhibited antinociceptive activity against writhing-induced pain by acetic acid. In the xylene ear edema test, olive oil showed significant anti-inflammatory activity in the mice.

DISCUSSION AND CONCLUSION:

The present data indicated that olive oil has antinociceptive and anti-inflammatory effects in mice but further investigation of these effects is required to elucidate the mechanism(s) involved in analgesic and anti-inflammatory effects of Olea europaea oil.

• Authors: Akram Eidi, Sara Moghadam-kia, Jalal Zarringhalam Moghadam, Maryam Eidi, Shamsali Rezazadeh
• Journal: Pharmaceutical biology (Pharm Biol) Vol. 50 Issue 3 Pg. 332-7 (Mar 2012) ISSN: 1744-5116 [Electronic] England
• PMID: 22085252 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Analgesics
• Anti-Inflammatory Agents
• Olive Oil
• Plant Oils

Topics

• Analgesics (administration & dosage, pharmacology)
• Animals
• Anti-Inflammatory Agents (administration & dosage, pharmacology)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Edema (drug therapy, physiopathology)
• Inflammation (drug therapy, physiopathology)
• Injections, Intraperitoneal
• Male
• Mice
• Mice, Inbred BALB C
• Olea (chemistry)
• Olive Oil
• Pain (drug therapy, physiopathology)
• Plant Oils (administration & dosage, pharmacology)