Claudins 10 and 18 are predominantly expressed in lung adenocarcinomas and in tumors of nonsmokers.

Abstract

AIMS:

We investigated the expression of claudins 18 and 10 in a large set of primary lung carcinomas.

METHODS AND RESULTS:

Immunohistochemical expression of claudin 18 was seen in 12.7 % and claudin 10 in 12.5 % of lung carcinomas. Their expression significantly associated with each other (p<0.001). The expression of claudin 18 and 10 was most prominent in lung adenocarcinomas which displayed positivity in 21.2% and 23.4 % of cases. Female patients had more often claudin 18 and 10 positive tumors, also separately in adenocarcinomas. Interestingly, claudin 10 (p=0.036) and claudin 18 (p=0.001) were more common in tumours of nonsmokers. In adenocarcinomas claudin 18 predicted a better survival (p=0.032). In Cox multivariate analysis, claudin 18 had an independent prognostic value (p=0.027).

CONCLUSION:

The results show that both claudins are most commonly expressed in lung adenocarcinomas and they are more occasionally detected in other histological tumour types. Curiously, female patients and non-smokers express these claudins more commonly suggesting that they may play a part in the carcinogenesis of tobacco unrelated carcinoma. Claudin 18 associated with a better survival in lung adenocarcinoma and had an independent prognostic value and may thus be used in the evaluation of patient prognosis.

• Authors: Heta Merikallio, Paavo Pääkkö, Terttu Harju, Ylermi Soini
• Journal: International journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 4 Issue 7 Pg. 667-73 ( 2011) ISSN: 1936-2625 [Electronic] United States
• PMID: 22076167 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• CLDN18 protein, human
• Claudins
• claudin 10

Topics

• Adenocarcinoma (chemistry, mortality, pathology)
• Adenocarcinoma of Lung
• Analysis of Variance
• Biomarkers, Tumor (analysis)
• Claudins (analysis)
• Female
• Finland (epidemiology)
• Humans
• Immunohistochemistry
• Kaplan-Meier Estimate
• Lung Neoplasms (chemistry, mortality, pathology)
• Male
• Prognosis
• Proportional Hazards Models
• Registries
• Risk Assessment
• Risk Factors
• Sex Factors
• Smoking (epidemiology)
• Survival Rate