In vitro effects of some herbs used in Egyptian traditional medicine on viability of protoscolices of hydatid cysts.

Abstract

The present work evaluated the effects of alcoholic extracts of salvia (Salvia officinalis), thyme (Thymus vulgaris), and 2 pure compounds (thymol and menthol) on the viability of Echinococcus granulosus protoscolices in vitro. Four different concentrations of each extract (2,500, 1,500, 1,000, and 500 µg/ml) and 3 different concentrations each of thymol and menthol (50, 10, and 1 µg/ml) were used. Concentration of 2,500 µg/ml of both extracts showed a significant protoscolicidal activity on the 6th day. Complete loss of viability of protoscolices occurred with 500 µg/ml concentration of both extracts at day 6 and day 7 post-treatment (PT), respectively. Pure compounds, i.e., menthol and thymol, showed potent effects with 50 µg/ml concentration at day 2 and day 5 PT, respectively. These effects were compared with those of albendazole sulfoxide (800 µg/ml), a commonly used treatment drug for hydatidosis. Krebs-Ringer solution and the hydatid cystic fluid at a ratio of 4:1 was a good preservative solution which kept the protoscolices viable for 15 days.

• Authors: Doaa A Yones, Gamal A Taher, Zedan Z Ibraheim
• Journal: The Korean journal of parasitology (Korean J Parasitol) Vol. 49 Issue 3 Pg. 255-63 (Sep 2011) ISSN: 1738-0006 [Electronic] Korea (South)
• PMID: 22072825 (Publication Type: Journal Article)

Chemical References

• Anthelmintics
• Plant Extracts

Topics

• Animals
• Anthelmintics (isolation & purification, pharmacology)
• Camelus
• Cell Survival (drug effects)
• Echinococcosis, Pulmonary (parasitology)
• Echinococcus granulosus (drug effects, isolation & purification)
• Lung (parasitology)
• Medicine, Traditional (methods)
• Plant Extracts (isolation & purification, pharmacology)
• Plants, Medicinal (chemistry)
• Salvia officinalis (chemistry)
• Thymus Plant (chemistry)
• Time Factors