Abstract | BACKGROUND: Rotavirus is a common neonatal nosocomial viral infection and epidemics with the newer P(6)G9 strains have been reported. Local mucosal immunity in the intestine to rotavirus is important in the resolution of infection and protection against subsequent infections. Oral administration of anti-rotaviral immunoglobulin preparations might be a useful strategy in preventing rotaviral infections, especially in low birth weight babies. OBJECTIVES: SEARCH METHODS: The Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library), MEDLINE, EMBASE, CINAHL, biological Abstracts (BIOSIS), Science Citation Index for articles citing Barnes 1982 and the proceedings of the Pediatric Academic Societies from 1991 onwards were searched in July 2011. Ongoing trials were also searched at clinicaltrials.gov and controlled-trials.com SELECTION CRITERIA: DATA COLLECTION AND ANALYSIS: The two review authors independently abstracted data from the included trials. MAIN RESULTS: One published study (Barnes 1982) was eligible for inclusion in this review. Barnes 1982 found no significant difference in the rates of rotavirus infection after oral gammaglobulin versus placebo in hospitalized low birthweight babies [RR 1.27 (95% CI 0.65 to 2.37)]. In the subset of infants who became infected with rotavirus after receiving gammaglobulin or placebo for prevention of rotavirus infection, there was no significant difference in the duration of rotavirus excretion between the group who had gammaglobulin (mean 2 days, range 1 to 4 days) and the group who had placebo (mean 3 days, range 1 to 6 days). Barnes 1982 reported no adverse effects after administration of oral immunoglobulin preparations. AUTHORS' CONCLUSIONS:
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Authors | Mohan Pammi, Khalid N Haque |
Journal | The Cochrane database of systematic reviews
(Cochrane Database Syst Rev)
Issue 11
Pg. CD003740
(Nov 09 2011)
ISSN: 1469-493X [Electronic] England |
PMID | 22071808
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review, Systematic Review)
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Chemical References |
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Topics |
- Administration, Oral
- Humans
- Immunization, Passive
(methods)
- Immunoglobulins
(administration & dosage)
- Infant, Low Birth Weight
- Infant, Newborn
- Randomized Controlled Trials as Topic
- Rotavirus Infections
(prevention & control, virology)
- Virus Shedding
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