Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: There was a statistically significant difference between PCOS and control groups (p<0.001) for hemolysate MDA while no difference was determined for either catalase or fasting blood glucose levels. On histopathological examination, the EV-induced PCOS group revealed disease-characteristic ovarian morphology. CONCLUSION: There was an increased compensation for oxidative stress by antioxidative biologic mechanisms in EV-induced PCOS rats. Interestingly, the sole result derived from this limited study is that the sesame oil+EV combination is not appropriate for the evaluation of oxidant- antioxidant status and also glycemic condition in PCOS. This study demonstrates the need for better designed experimental studies to elucidate the aetiopathogenesis of PCOS via novel techniques.
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Authors | Aysegul Dikmen, Ahmet Mete Ergenoglu, Ahmet Ozgur Yeniel, Ozlem Yilmaz Dilsiz, Gulinnaz Ercan, Huseyin Yilmaz |
Journal | European journal of obstetrics, gynecology, and reproductive biology
(Eur J Obstet Gynecol Reprod Biol)
Vol. 160
Issue 1
Pg. 55-9
(Jan 2012)
ISSN: 1872-7654 [Electronic] Ireland |
PMID | 22071112
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Blood Glucose
- Estradiol
- Catalase
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Topics |
- Animals
- Blood Glucose
(analysis)
- Catalase
(metabolism)
- Disease Models, Animal
- Estradiol
(analogs & derivatives, toxicity)
- Female
- Lipid Peroxidation
- Oxidative Stress
- Polycystic Ovary Syndrome
(chemically induced, metabolism, pathology)
- Rats
- Rats, Wistar
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