Lymphomatoid papulosis in children: experience of five cases and the treatment efficacy of methotrexate.

Abstract

We present a case series of childhood lymphomatoid papulosis (LyP), an entity which is commonly misdiagnosed and poorly described in the paediatric dermatology literature. Clinically and histologically, the features of LyP in children can mimic insect bite reactions, with prominent dermal neutrophils and eosinophils. However, CD30 immunohistochemical staining of atypical lymphocytes within a mixed inflammatory infiltrate should point to the diagnosis of LyP. There is no consensus to guide management of childhood LyP due to its rarity and largely unknown natural course. We discuss our experience with LyP in five children and the use of methotrexate to induce rapid resolution of persistent lesions and to reduce recurrences in two children. Although none of our cases have experienced malignant transformation to date, life-long monitoring is advocated.

• Authors: Leona Yip, Sandy Darling, David Orchard
• Journal: The Australasian journal of dermatology (Australas J Dermatol) Vol. 52 Issue 4 Pg. 279-83 (Nov 2011) ISSN: 1440-0960 [Electronic] Australia
• PMID: 22070703 (Publication Type: Journal Article)
• Copyright: © 2011 The Authors; Australasian Journal of Dermatology © 2011 The Australasian College of Dermatologists.

Chemical References

• Antimetabolites, Antineoplastic
• Methotrexate

Topics

• Adolescent
• Antimetabolites, Antineoplastic (therapeutic use)
• Child
• Child, Preschool
• Female
• Humans
• Infant
• Lymphomatoid Papulosis (diagnosis, drug therapy)
• Male
• Methotrexate (therapeutic use)
• Skin Neoplasms (diagnosis, drug therapy)