Mast cell stabilization: novel medication for obesity and diabetes.

Abstract

Mast cells are essential in allergic responses and beyond. White adipose tissue from obese humans contains large numbers of mast cells. Serum mast cell tryptase levels are also significantly higher in obese subjects than in lean subjects, suggesting a role of these inflammatory cells in obesity and diabetes. Two types of mast cell-deficient mice, along with corresponding wild-type control mice, were fed a Western diet to induce obesity and diabetes. We also used two anti-allergy drugs, cromolyn and ketotifen (Zaditor), to treat wild-type mice during intake of a Western diet or after the onset of obesity and diabetes, to examine the possible prevention or reversal of these conditions. Mast cell deficiency or pharmacological stabilization reduced body weight gain and improved glucose and insulin sensitivities. These common, side effect-free drugs also reduced pre-established obesity and diabetes without noticeable toxicity. Mechanistic studies suggest that mast cells participate in these metabolic disorders by affecting energy expenditure, protease expression, angiogenesis, apoptosis, and preadipocyte differentiation. These observations open a new era of basic research regarding mast cells, and offer hope to patients suffering from these metabolic disorders.

• Authors: Jing Wang, Guo-Ping Shi
• Journal: Diabetes/metabolism research and reviews (Diabetes Metab Res Rev) Vol. 27 Issue 8 Pg. 919-24 (Nov 2011) ISSN: 1520-7560 [Electronic] England
• PMID: 22069285 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 John Wiley & Sons, Ltd.

Chemical References

• Cromolyn Sodium
• Ketotifen

Topics

• Animals
• Cromolyn Sodium (therapeutic use)
• Diabetes Mellitus (drug therapy)
• Insulin Resistance
• Ketotifen (therapeutic use)
• Mast Cells (drug effects, physiology)
• Mice
• Obesity (drug therapy)
• Weight Gain (drug effects)