Miliaria-rash after neutropenic fever and induction chemotherapy for acute myelogenous leukemia.

Abstract

Miliaria is a disorder of the eccrine sweat glands which occurs in conditions of increased heat and humidity. It can be associated with persistent febrile states as well as with certain drugs. We presented a 40 year-old female with myelodysplastic syndrome and progression to acute myelogenous leukemia who was admitted to the hospital for chemotherapy induction. The patient was treated with idarubicin and cytarabine. She became pancytopenic and developed neutropenic fever and was started on vancomycin and cefepime, but was persistently febrile with night sweats. Five days into her fevers, she developed diffuse, nonpruritic and fragile vesicles together with drenching nightsweats. The patient's exanthem was diagnosed as Miliaria crystallina, most probably induced by neutropenic fever and idarubucin exposure.

• Authors: Tuyet A Nguyen, Alex G Ortega-Loayza, Michael P Stevens
• Journal: Anais brasileiros de dermatologia (An Bras Dermatol) 2011 Jul-Aug Vol. 86 Issue 4 Suppl 1 Pg. S104-6 ISSN: 1806-4841 [Electronic] Spain
• PMID: 22068785 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Cytarabine
• Idarubicin

Topics

• Adult
• Antibiotics, Antineoplastic (adverse effects, therapeutic use)
• Cytarabine (therapeutic use)
• Female
• Fever (etiology)
• Humans
• Idarubicin (adverse effects, therapeutic use)
• Induction Chemotherapy (adverse effects)
• Leukemia, Myeloid, Acute (drug therapy)
• Miliaria (chemically induced, pathology)
• Neutropenia (chemically induced, complications)