Abstract | INTRODUCTION: AREAS COVERED: This review describes the physical and chemical properties of hyaluronic acid and examines the role of hyaluronic acid in wound healing, in particular on the tympanic membrane. It also reviews the safety and efficacy of hyaluronic acid and its derivatives in animal studies as well as in clinical trials. Finally, it considers the potential future clinical applications in tympanic membrane perforation repair. EXPERT OPINION:
Hyaluronic acid has been found to accelerate tympanic membrane perforation closure, shorten the period of healing, produce a better quality neo-membrane and improve hearing. More importantly, hyaluronic acid is biodegradable, safe and biocompatible in the ear. Recently, there has been a trend towards the use of modified hyaluronic acid. However, there is a lack of higher-level evidence to support the use of hyaluronic acid in tympanic membrane perforations in the clinical setting. More large-scale randomised control trials are warranted before these bio-devices will be used routinely.
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Authors | Bing Mei Teh, Yi Shen, Peter L Friedland, Marcus D Atlas, Robert J Marano |
Journal | Expert opinion on biological therapy
(Expert Opin Biol Ther)
Vol. 12
Issue 1
Pg. 23-36
(Jan 2012)
ISSN: 1744-7682 [Electronic] England |
PMID | 22059535
(Publication Type: Journal Article, Review)
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Chemical References |
- Biocompatible Materials
- Hyaluronic Acid
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Topics |
- Acoustics
- Animals
- Biocompatible Materials
(chemistry)
- Clinical Trials as Topic
- Elasticity
- Humans
- Hyaluronic Acid
(chemistry, metabolism, pharmacology)
- Models, Chemical
- Randomized Controlled Trials as Topic
- Safety
- Tympanic Membrane
(drug effects, injuries)
- Tympanic Membrane Perforation
(drug therapy)
- Viscosity
- Wound Healing
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