Abstract | CONCLUSIONS: OBJECTIVES: Despite the importance of understanding changes in neurotransmitters during presbycusis, only a few studies have assessed age-associated changes in neurotransmitter at each level of the CAS. We therefore evaluated effects of aging on neurotransmission in the CAS of rats. METHODS: The concentrations of serotonin, NMDAR, and GAD were assayed immunohistochemically in the cochlear nucleus (CN), superior olivary nucleus (SON), inferior colliculus (IC), medial geniculate body (MGB), and auditory cortex (AC) of Sprague-Dawley rats, aged 2 weeks (n = 20) or 24 months (n = 20). RESULTS: The total number of neuronal cell bodies of the CAS did not differ significantly at each level between young and aged rats (p > 0.05). Serotonin expression was increased with age in the IC and MGB, but decreased in the CN, SON, and AC (p < 0.05). NMDAR was significantly higher in the CN, MGB, and AC of aged compared with young rats, but was significantly decreased over time in the SOC and IC (p < 0.05). GAD67 was increased with age in the MGB and AC and decreased in the CN and SON (p < 0.05), but was not changed in the IC.
|
Authors | Hyun Joon Shim, Lae Hyung Lee, Youngbuhm Huh, So Yoon Lee, Seung Geun Yeo |
Journal | Acta oto-laryngologica
(Acta Otolaryngol)
Vol. 132
Issue 1
Pg. 44-50
(Jan 2012)
ISSN: 1651-2251 [Electronic] England |
PMID | 22054020
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Serotonin
- N-Methylaspartate
- Glutamate Decarboxylase
|
Topics |
- Aging
(metabolism)
- Animals
- Auditory Cortex
(metabolism)
- Cochlear Nucleus
(metabolism)
- Geniculate Bodies
(metabolism)
- Glutamate Decarboxylase
(biosynthesis)
- Immunohistochemistry
- Inferior Colliculi
(metabolism)
- Male
- N-Methylaspartate
(biosynthesis)
- Rats
- Rats, Sprague-Dawley
- Serotonin
(biosynthesis)
- Synaptic Transmission
|