Osteoid osteoma and osteoblastoma.

Abstract

Osteoid osteoma and osteoblastoma are commonly seen benign osteogenic bone neoplasms. Both tumors are typically seen in the second decade of life, with a notable predilection in males. Histologically, these tumors resemble each other, with characteristically increased osteoid tissue formation surrounded by vascular fibrous stroma and perilesional sclerosis. However, osteoblastomas are larger than osteoid osteomas, and they exhibit greater osteoid production and vascularity. Clinically, osteoid osteoma most commonly occurs in the long bones (eg, femur, tibia). The lesions cause night pain that is relieved with nonsteroidal anti-inflammatory drugs (NSAIDs). Osteoblastoma is most frequently located in the axial skeleton, and the pain is usually not worse at night and is less likely to be relieved with NSAIDs. Osteoblastoma can be locally aggressive; osteoid osteoma lacks growth potential. Osteoid osteoma may be managed nonsurgically with NSAIDs. When surgery is required, minimally invasive methods (eg, CT-guided excision, radiofrequency ablation) are preferred. Osteoblastoma has a higher rate of recurrence than does osteoid osteoma, and patients must be treated surgically with intralesional curettage or en bloc resection.

• Authors: Kivanc I Atesok, Benjamin A Alman, Emil H Schemitsch, Amos Peyser, Henry Mankin
• Journal: The Journal of the American Academy of Orthopaedic Surgeons (J Am Acad Orthop Surg) Vol. 19 Issue 11 Pg. 678-89 (Nov 2011) ISSN: 1067-151X [Print] United States
• PMID: 22052644 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal

Topics

• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Bone Neoplasms (diagnosis, surgery)
• Catheter Ablation
• Diagnostic Imaging
• Humans
• Magnetic Resonance Imaging
• Neoplasm Recurrence, Local
• Osteoblastoma (diagnosis, surgery)
• Osteoma, Osteoid (diagnosis, surgery)
• Prognosis