Role of FDG-PET as a biological marker for predicting the hypoxic status of tongue cancer.

Abstract

BACKGROUND:

To determine whether 2-[(18)F]fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) could serve as a useful technique predicting tumor hypoxia and prognosis in tongue cancer, we assessed the relationship between FDG uptake and the levels of hypoxia-related markers.

METHODS:

Tumor uptake of FDG in 33 patients with T2 tongue cancer was assessed by measuring maximum standardized uptake values (SUVmax). Expression of hypoxia-inducible factor (HIF)-1α, carbonic anhydrase (CA)-9, glucose transporter (GLUT)-1, and erythropoietin receptor (EPOR), was determined by immunohistochemical staining. Correlation between SUVmax and the expression of hypoxia-related markers was assessed and multivariate analysis was performed to determine what parameters affected clinical outcomes.

RESULTS:

We observed strong correlations between SUVmax and expression of HIF-1α (p < .05), CA-9 (p < .01), and GLUT-1 (p < .01). SUVmax, HIF-1α expression, and tumor grade were significant independent predictors of disease-free survival (DFS).

CONCLUSION:

SUVmax may be a good noninvasive biomarker for prediction of hypoxic status and prognosis of patients with T2 tongue cancer.

• Authors: Myung Woul Han, Hee Jin Lee, Kyung-Ja Cho, Jae Seung Kim, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
• Journal: Head & neck (Head Neck) Vol. 34 Issue 10 Pg. 1395-402 (Oct 2012) ISSN: 1097-0347 [Electronic] United States
• PMID: 22052623 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Wiley Periodicals, Inc.

Chemical References

• Biomarkers
• Hypoxia-Inducible Factor 1, alpha Subunit
• Peptide Fragments
• Receptors, Erythropoietin
• erythropoietin receptor (1-225)
• Fluorodeoxyglucose F18
• Carbonic Anhydrases

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers (metabolism)
• Biopsy, Needle
• Carbonic Anhydrases (metabolism)
• Carcinoma, Squamous Cell (diagnostic imaging, mortality, pathology, surgery)
• Cohort Studies
• Disease-Free Survival
• Female
• Fluorodeoxyglucose F18 (pharmacokinetics)
• Follow-Up Studies
• Humans
• Hypoxia (diagnostic imaging, physiopathology)
• Hypoxia-Inducible Factor 1, alpha Subunit (metabolism)
• Immunohistochemistry
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Multivariate Analysis
• Neck Dissection (methods)
• Peptide Fragments (metabolism)
• Positron-Emission Tomography (methods)
• Predictive Value of Tests
• Preoperative Care
• Proportional Hazards Models
• Receptors, Erythropoietin (metabolism)
• Registries
• Retrospective Studies
• Risk Assessment
• Survival Analysis
• Tongue Neoplasms (diagnostic imaging, mortality, pathology, surgery)
• Treatment Outcome