Rapid injection of propofol reduces vascular pain and facilitates Laryngeal Mask Airway insertion.

Abstract

STUDY OBJECTIVE:

To compare the clinical efficacy of a rapid injection of propofol in regard to pain and ability to facilitate Laryngeal Mask Airway (LMA) insertion.

DESIGN:

Randomized, single-blinded, placebo-controlled study.

SETTING:

University hospital.

PATIENTS:

120 ASA physical status 1 and 2 patients undergoing elective orthopedic surgeries.

INTERVENTIONS:

Patients were randomly allocated to one of 4 groups. Group A patients were pretreated with normal saline followed by propofol 2.0 mg/kg at 3.3 mg/sec. Group B patients were pretreated with lidocaine 0.5 mg/kg followed by propofol 2.0 mg/kg at 3.3 mg/sec. In Group C, patients were pretreated with lidocaine 1.0 mg/kg followed by propofol 2.0 mg/kg at 3.3 mg/sec. In Group D, patients were pretreated with normal saline followed by propofol 2.0 mg/kg at 50 mg/sec.

MEASUREMENTS:

Pain on injection was measured using a 4-point scale. Scale and success rate of smooth LMA insertion also were recorded.

MAIN RESULTS:

Rapid injection was less painful than after pretreatment with lidocaine 0.5 mg/kg, but was similar to slow injection after pretreatment with lidocaine 1.0 mg/kg. Rapid injection facilitated LMA insertion, unlike slow injection with lidocaine 0.5 mg/kg pretreatment, and was similarly successful to slow injection after pretreatment with lidocaine 1.0 mg/kg.

CONCLUSIONS:

The rapid administration of propofol reduces pain and facilitates LMA insertion versus slow administration of propofol.

• Authors: Takeru Shimizu, Shinichi Inomata, Makoto Tanaka
• Journal: Journal of clinical anesthesia (J Clin Anesth) Vol. 23 Issue 7 Pg. 540-3 (Nov 2011) ISSN: 1873-4529 [Electronic] United States
• PMID: 22050796 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Anesthetics, Intravenous
• Anesthetics, Local
• Lidocaine
• Propofol

Topics

• Adult
• Aged
• Anesthetics, Intravenous (administration & dosage, adverse effects)
• Anesthetics, Local (therapeutic use)
• Female
• Hospitals, University
• Humans
• Laryngeal Masks
• Lidocaine (therapeutic use)
• Male
• Middle Aged
• Pain (chemically induced, prevention & control)
• Propofol (administration & dosage, adverse effects)
• Prospective Studies
• Single-Blind Method
• Young Adult