Abstract | STUDY OBJECTIVE: To compare the clinical efficacy of a rapid injection of propofol in regard to pain and ability to facilitate Laryngeal Mask Airway (LMA) insertion. DESIGN: Randomized, single-blinded, placebo-controlled study. SETTING: University hospital. PATIENTS: INTERVENTIONS: Patients were randomly allocated to one of 4 groups. Group A patients were pretreated with normal saline followed by propofol 2.0 mg/kg at 3.3 mg/sec. Group B patients were pretreated with lidocaine 0.5 mg/kg followed by propofol 2.0 mg/kg at 3.3 mg/sec. In Group C, patients were pretreated with lidocaine 1.0 mg/kg followed by propofol 2.0 mg/kg at 3.3 mg/sec. In Group D, patients were pretreated with normal saline followed by propofol 2.0 mg/kg at 50 mg/sec. MEASUREMENTS:
Pain on injection was measured using a 4-point scale. Scale and success rate of smooth LMA insertion also were recorded. MAIN RESULTS: Rapid injection was less painful than after pretreatment with lidocaine 0.5 mg/kg, but was similar to slow injection after pretreatment with lidocaine 1.0 mg/kg. Rapid injection facilitated LMA insertion, unlike slow injection with lidocaine 0.5 mg/kg pretreatment, and was similarly successful to slow injection after pretreatment with lidocaine 1.0 mg/kg. CONCLUSIONS: The rapid administration of propofol reduces pain and facilitates LMA insertion versus slow administration of propofol.
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Authors | Takeru Shimizu, Shinichi Inomata, Makoto Tanaka |
Journal | Journal of clinical anesthesia
(J Clin Anesth)
Vol. 23
Issue 7
Pg. 540-3
(Nov 2011)
ISSN: 1873-4529 [Electronic] United States |
PMID | 22050796
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Anesthetics, Intravenous
- Anesthetics, Local
- Lidocaine
- Propofol
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Topics |
- Adult
- Aged
- Anesthetics, Intravenous
(administration & dosage, adverse effects)
- Anesthetics, Local
(therapeutic use)
- Female
- Hospitals, University
- Humans
- Laryngeal Masks
- Lidocaine
(therapeutic use)
- Male
- Middle Aged
- Pain
(chemically induced, prevention & control)
- Propofol
(administration & dosage, adverse effects)
- Prospective Studies
- Single-Blind Method
- Young Adult
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