Pralidoxime in organophosphorus poisoning.

Abstract

INTRODUCTION:

Pralidoxime are enzyme reactivator that are known to reactivate the phosphorylated acetylcholinesterase by binding to the organophosphorus molecule. The use of oximes in acute organophosphorus poisoning has been a controversial subjects for over two decades. This study was conducted with the objective to find out the estimation of serum cholinesterase and use of pralidoxime in organophosphorus poisoning.

METHODS:

A prospective analysis of all organophosphorus poisoning cases presented at the Emergency Department, Tribhuvan University Teaching Hospital for seven months was done.

RESULTS:

Out of 26 cases about 60% of poisoning cases were monitored for pseudocholinesterase level. About 50% of them had pseudocholinesterase level within normal limit and 20% had less than 10% of normal value. Only 33% cases with pseudocholinesterase level less than 10% were treated with pralidoxime.

CONCLUSIONS:

The initial dose of Pralidoxime used was 1 gm followed by maintenance dose of 500mg 6 hourly, the doses prescribed were less than WHO recommended doses.

• Authors: N R Simkhada, K K Kafle, P N Prasad
• Journal: JNMA; journal of the Nepal Medical Association (JNMA J Nepal Med Assoc) 2010 Oct-Dec Vol. 50 Issue 180 Pg. 300-2 ISSN: 0028-2715 [Print] Nepal
• PMID: 22049895 (Publication Type: Journal Article)

Chemical References

• Cholinesterase Reactivators
• Pralidoxime Compounds
• pralidoxime

Topics

• Cholinesterase Reactivators (therapeutic use)
• Cross-Sectional Studies
• Female
• Humans
• Male
• Organophosphate Poisoning
• Pralidoxime Compounds (therapeutic use)
• Prospective Studies
• Surveys and Questionnaires
• Treatment Outcome