Abstract | BACKGROUND: METHODS: Ninety-eight patients with advanced or recurrent GIST were treated with imatinib mesylate. Among the fifty-seven male patients six developed gynecomastia during the treatment. The lesions were confirmed by sonography. Sex hormone levels were determined in six patients with and without the presence of gynecomastia respectively. The patients with gynecomatia were treated with tamoxifene and the sex hormones were assayed before and after tamoxifene treatment. RESULTS: In patients with gynecomastia the lump underneath the bilateral nipples was 2.5 to 5 centimeters in diameter. Their serum free testosterone levels ranged between 356.61 and 574.60 ng/dl with a mean ± SD of 408.64 ± 82.06 ng/dl (95% CI 343.03~474.25 ng/dl), which is within the normal range. The level of serum estradiol was 42.89 ± 16.54 pg/ml (95% CI 29.66~56.12 pg/ml). Three patients had higher levels (43.79~71.21 pg/ml) and the others' were within normal range of 27.00~34.91 pg/ml. Six patients without the development of gynecomastia had normal free testosterone. One patient died because of large tumor burden. The sex hormones had no significant changes before and after tamoxifene treatment.(P > 0.05) CONCLUSIONS:
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Authors | HeLi Liu, GuoQing Liao, ZhongShu Yan |
Journal | BMC gastroenterology
(BMC Gastroenterol)
Vol. 11
Pg. 116
(Nov 02 2011)
ISSN: 1471-230X [Electronic] England |
PMID | 22047550
(Publication Type: Journal Article)
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Chemical References |
- Benzamides
- Estrogen Antagonists
- Piperazines
- Protein Kinase Inhibitors
- Pyrimidines
- Tamoxifen
- Testosterone
- Estradiol
- Imatinib Mesylate
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Topics |
- Adult
- Aged
- Benzamides
- Estradiol
(blood)
- Estrogen Antagonists
(therapeutic use)
- Female
- Gastrointestinal Stromal Tumors
(blood, drug therapy)
- Gynecomastia
(chemically induced, drug therapy)
- Humans
- Imatinib Mesylate
- Male
- Middle Aged
- Piperazines
(adverse effects)
- Protein Kinase Inhibitors
(adverse effects)
- Pyrimidines
(adverse effects)
- Tamoxifen
(therapeutic use)
- Testosterone
(blood)
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