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High total acrosin activity in varicocele individuals.

Abstract
Varicocele is a common cause of male infertility and reports indicate that varicocelectomy has a beneficial effect on male fertility. The aims of this study were to evaluate and compare the total acrosin activity along with DNA integrity in semen samples obtained from 70 varicocele individuals with male factors infertility presenting grades II and III varicocele before and after the surgery and 30 fertile individuals without any clinical presentation of varicocele. Total acrosin activity, protamine deficiency, DNA fragmentation, and semen parameters including sperm concentration, motility and sperm morphology were assessed by spectrophotometery, CMA3 staining, terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) assay and WHO criteria, respectively. Total acrosin activity (P = 0.03), percentage CMA3 positivity (P = 0.00) and TUNEL-positive spermatozoa (P = 0.04) were higher in the varicocele individuals before the surgery compared with the fertile individuals; yet, all the aforementioned criteria decreased significantly after surgery (P < 0.05). The results of this study reveal that DNA fragmentation and protamine deficiency, as negative parameters in fertility, improve post-surgery; however, total acrosin activity as a positive parameter in fertility is higher in the varicocele individuals compared with fertile and decreases to a value close to the fertile control post-surgery. High levels of total acrosin activity in varicocele individuals need more research in future.
AuthorsE Navaeian-Kalat, M R Deemeh, M Tavalaee, H Abasi, M Modaresi, M H Nasr-Esfahani
JournalAndrologia (Andrologia) Vol. 44 Suppl 1 Pg. 634-41 (May 2012) ISSN: 1439-0272 [Electronic] Germany
PMID22044345 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2011 Blackwell Verlag GmbH.
Chemical References
  • Acrosin
Topics
  • Acrosin (metabolism)
  • Humans
  • In Situ Nick-End Labeling
  • Male
  • Varicocele (metabolism)

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