HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Occupational risks and lung cancer burden for Chinese men: a population-based case-referent study.

AbstractOBJECTIVE:
We aimed to fill in the gap of knowledge on the lung cancer burden resulting from occupational exposures among Chinese men through a population-based case-referent study.
METHODS:
Detailed information on lifestyle and full occupational histories of 1,208 male lung cancer incident cases and 1,069 age-matched male community referents were obtained through interviews during 2004-2006. The associations between lung cancer risk and exposures to specific or group of agents that were confirmed or suspected occupational carcinogens were analyzed.
RESULTS:
After adjustment of smoking and other potential confounding factors, significant odds ratio of lung cancer was observed for workers employed in major industrial divisions of "construction" (1.37, 95% CI: 1.00-1.89) and "financing, insurance, real estate, and business services" (0.48, 95% CI: 0.23-0.97), as well as in the occupational groups of "bricklayers, carpenters, and other construction workers" (1.49, 95% CI: 1.07-2.06). Significantly elevated odds ratios were found for occupational exposures to silica dust (1.75, 95% CI: 1.16-2.62), welding fumes (1.74, 95% CI: 1.13-2.68), diesel exhaust (2.18, 95% CI: 1.23-3.84), and man-made mineral fibers (7.45, 95% CI: 1.63-34.00), while a significantly reduced risk (OR = 0.67, 95% CI: 0.47-0.95) was linked to cotton dust. The population attributable fraction of lung cancer was 3.2% (95% CI: 0.1-7.3%) for construction workers and 9.5% (95% CI: 4.8-15.1%) for the four significant specific exposures.
CONCLUSIONS:
Our study indicates that previous exposure to occupational carcinogens remains an important determinant of lung cancer burden for Hong Kong Chinese men. However, results obtained from this study should be confirmed by future analyses based on job exposure matrix.
AuthorsLap Ah Tse, Ignatius Tak-Sun Yu, Hong Qiu, Joseph Siu Kai Au, Xiao-Rong Wang
JournalCancer causes & control : CCC (Cancer Causes Control) Vol. 23 Issue 1 Pg. 121-31 (Jan 2012) ISSN: 1573-7225 [Electronic] Netherlands
PMID22037909 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carcinogens
Topics
  • Aged
  • Carcinogens (analysis)
  • China (epidemiology)
  • Humans
  • Lung Neoplasms (epidemiology, etiology)
  • Male
  • Middle Aged
  • Occupational Diseases (epidemiology, etiology)
  • Occupational Exposure (adverse effects)
  • Occupations (statistics & numerical data)
  • Outcome Assessment (Health Care)
  • Registries
  • Risk Factors
  • Socioeconomic Factors
  • Surveys and Questionnaires

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: