Interleukin-6 plasmatic levels in patients with head trauma and intracerebral hemorrhage.

Abstract

The exact role of inflammatory response in hemorrhagic contusions is not fully characterized. The present study quantified IL-6 plasmatic levels in patients with closed head trauma and hemorrhagic contusions during the first 6 to 12 hours postrauma. The association between the plasmatic IL-6 levels, severity of trauma according to the Glasgow Coma Scale, volume of intracerebral hemorrhage and patient's clinical evolution were investigated. Although inflammation is a multifactorial process, a strong correlation between IL-6 levels, volume of traumatic hemorrhage and in-hospital evolution could be observed. A correlation between the IL-6 levels quantified 6 hours postrauma and progression of lesion volume between admission and 12 hours postrauma is suggested. The present study reinforces the importance of IL-6 in influencing the clinical conditions of a patient with cerebral injuries, particularly hemorrhagic contusions.

• Authors: Alessandra Armstrong Antunes, Vanessa Santos Sotomaior, Keyth Suga Sakamoto, Cyro Pereira de Camargo Neto, Carolina Martins, Luiz Roberto Aguiar
• Journal: Asian journal of neurosurgery (Asian J Neurosurg) Vol. 5 Issue 1 Pg. 68-77 (Jan 2010) ISSN: 2248-9614 [Electronic] India
• PMID: 22028746 (Publication Type: Journal Article)