Biochemical and molecular characterization of von Willebrand disease type 2N in a pregnant patient who gave birth under analgesia with remifentanil.

Abstract

von Willebrand 's disease (vWD) is the commonest inherited bleeding disorder. Although in literature there are some cases reported of epidural analgesia for labor pain in pregnancies with Von Willebrand's disease, the technique is not free from risk of neurolocal complications. Authors reported a case of spontaneous labor in a pregnant woman with type II vWD, delivered under local analgesia administered through a continuous intravenous infusion of remifentanil integrated by boli. A 34-year-old woman at the 39th week of her second pregnancy was admitted for an active labor of a single fetus in cephalic presentation. The patient had been diagnosed with type II vWD by a hematologist during her first pregnancy. The patient coagulation panel was as follows: a reduction of VIIIth factor concentration (21 percent); a normal value of vWD functional assay; an increase of vWf:Ag (antigen) and a reduction of XIth factor. During labor she was put on remifentanil in PCA (patient controlled analgesia), administered with slow boli followed by continuous infusions at increasing doses. The woman delivered a female fetus weighing 3,550 g, in vertex presentation, in left anterior occipital position, with an A.P.G.A.R. of 8 at the first minute and 9 at the fifth minute. The total duration of labor was 3 hours and 10 minutes. The patient was satisfied with analgesia in labor. The bleeding during and after delivery was regular. In the authors ' opinion, it is important to know that an alternative to epidural analgesia can be used in order to avoid the risk of neurological complications in labor pain for patients with type II Von Willebrand's disease.

• Authors: D Dell'Edera, P Guanciali Franchi, M B Lioi, A A Epifania, A Tinelli, V Monti Condesnitt, A Brizzi, A Malvasi
• Journal: Journal of biological regulators and homeostatic agents (J Biol Regul Homeost Agents) 2011 Jul-Sep Vol. 25 Issue 3 Pg. 469-75 ISSN: 0393-974X [Print] Italy
• PMID: 22023773 (Publication Type: Case Reports, Letter)

Chemical References

• Anesthetics, Intravenous
• Piperidines
• Factor VIII
• Factor XI
• Remifentanil

Topics

• Adult
• Analgesia, Epidural
• Anesthetics, Intravenous (administration & dosage)
• Factor VIII (metabolism)
• Factor XI (metabolism)
• Female
• Humans
• Pain (blood, prevention & control)
• Piperidines (administration & dosage)
• Pregnancy (blood)
• Pregnancy Complications, Hematologic (blood)
• Remifentanil
• Term Birth (blood)
• von Willebrand Disease, Type 2 (blood)