Acute cortical necrosis following renal transplantation in a case of sickle cell trait.

Abstract

Renal transplant recipients who have sickle cell disease are at risk of infection, recurrent graft disease, and sickling crisis that affects the long-term outcome. We report a patient of sickle cell trait who developed patchy cortical necrosis in the perioperative period but had a good long-term outcome. The renal cortical necrosis was presumed to be secondary to cyclosporine-basiliximab interaction in the backdrop of sickling trait. The patient additionally had spontaneous closure of vascular access and severe hypertension immediately following transplantation suggestive of vaso-occlusive crisis. Cyclosporine and basiliximab drug interaction needs to be recognized and steps need to be taken in patients to avoid perioperative graft dysfunction.

• Authors: S Shiradhonkar, R Jha, B S Rao, G Narayan, S Sinha, G Swarnalata
• Journal: Indian journal of nephrology (Indian J Nephrol) Vol. 21 Issue 4 Pg. 286-8 (Oct 2011) ISSN: 1998-3662 [Electronic] India
• PMID: 22022093 (Publication Type: Case Reports)