A 79-year-old woman was admitted to a nearby hospital for seven days due to low-grade
fever, loss of appetite and general
fatigue. She was diagnosed with normal condition and discharged. She was admitted to our hospital one week later with disturbed consciousness. Laboratory findings upon admission revealed
anemia, elevated
alanine amino
transferase, elevated total birirubin and
thrombocytopenia. Abdominal CT demonstrated multiple low intensity lesions in the liver. Enhanced brain CT revealed multiple lesions with increased signal intensity lesions in the white matter and cortex. The value of soluble
IL-2 receptor antibody was 16,000U/ml. Intravascular
lymphoma was suspected because of brain CT finding and
IL-2 receptor antibody titer.
Methylprednisolone pulse
therapy was started considering her age and general condition, but she was died thirteen days after admission. Postmorten examination revealed widespread intravascular aggregation of
malignant lymphoma cells in the liver, spleen, bone marrow, bladder, ovary and stomach indicating a diagnosis of an Asian variant of intravascular large
B cell lymphoma (AIVL). Neurological abnormalities are not usually associated with AIVL, but this patient had rare AIVL presenting with initial progressive nonspecific neurological symptoms.