Cancer incidence of 2,4-D production workers.

Abstract

Despite showing no evidence of carcinogenicity in laboratory animals, the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) has been associated with non-Hodgkin lymphoma (NHL) in some human epidemiology studies, albeit inconsistently. We matched an existing cohort of 2,4-D manufacturing employees with cancer registries in three US states resulting in 244 cancers compared to 276 expected cases. The Standardized Incidence Ratio (SIR) for the 14 NHL cases was 1.36 (95% Confidence Interval (CI) 0.74-2.29). Risk estimates were higher in the upper cumulative exposure and duration subgroups, yet not statistically significant. There were no clear patterns of NHL risk with period of hire and histology subtypes. Statistically significant results were observed for prostate cancer (SIR = 0.74, 95% CI 0.57-0.94), and "other respiratory" cancers (SIR = 3.79, 95% CI 1.22-8.84; 4 of 5 cases were mesotheliomas). Overall, we observed fewer cancer cases than expected, and a non statistically significant increase in the number of NHL cases.

• Authors: Carol Burns, Kenneth Bodner, Gerard Swaen, James Collins, Kathy Beard, Marcia Lee
• Journal: International journal of environmental research and public health (Int J Environ Res Public Health) Vol. 8 Issue 9 Pg. 3579-90 (09 2011) ISSN: 1660-4601 [Electronic] Switzerland
• PMID: 22016704 (Publication Type: Journal Article)

Chemical References

• Air Pollutants, Occupational
• Herbicides
• 2,4-Dichlorophenoxyacetic Acid

Topics

• 2,4-Dichlorophenoxyacetic Acid (toxicity)
• Adult
• Aged
• Air Pollutants, Occupational (toxicity)
• Chemical Industry
• Cohort Studies
• Herbicides (toxicity)
• Humans
• Incidence
• Lymphoma, Non-Hodgkin (epidemiology)
• Male
• Michigan (epidemiology)
• Middle Aged
• Occupational Exposure
• Young Adult