Abstract | PURPOSE: METHODS: Seven eyes of seven patients with Behcet disease were assessed. Patients had unilaterally active retinal vasculitis that failed to respond to conventional treatment, together with a history of increased intraocular pressure or intolerance to corticosteroid administration. Intravitreal injection of 400 μg MTX was given monthly until visual acuity and intraocular inflammation were stable. Aqueous humor samples were obtained from the patients before MTX injection and from nine eyes during cataract surgery as a control group. Changes in visual acuity with the Early Treatment Diabetic Retinopathy Study Chart, fluorescein angiographic leakage, and ocular complications associated with intravitreal injection were analyzed. Aqueous humor cytokine levels were measured by proteomic analysis using a multianalyte biochip array system. RESULTS: CONCLUSION:
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Authors | Jeong Hun Bae, Sung Chul Lee |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 32
Issue 7
Pg. 1395-402
(Jul 2012)
ISSN: 1539-2864 [Electronic] United States |
PMID | 22012204
(Publication Type: Journal Article)
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Chemical References |
- Cytokines
- Immunosuppressive Agents
- Methotrexate
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Topics |
- Adolescent
- Adult
- Aqueous Humor
(metabolism)
- Behcet Syndrome
(complications, drug therapy, metabolism)
- Cytokines
(metabolism)
- Female
- Fluorescein Angiography
- Humans
- Immunosuppressive Agents
(administration & dosage, therapeutic use)
- Intraocular Pressure
(physiology)
- Intravitreal Injections
- Male
- Methotrexate
(administration & dosage, therapeutic use)
- Middle Aged
- Retinal Vasculitis
(complications, drug therapy, metabolism)
- Retrospective Studies
- Treatment Outcome
- Visual Acuity
(physiology)
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