Treatment of sexually transmitted vaginosis/vaginitis.

Abstract

Although much has been learned about sexually transmissible forms of vaginitis/vaginosis during the past decade, therapeutic options for these disorders remain limited. A single 2-g oral dose of metronidazole still remains highly effective against most Trichomonas vaginalis infections. Mildly resistant infections can usually be cured with metronidazole oral doses of 2 g daily for 3-7 days. When highly resistant infections occur, toxic levels of metronidazole may be needed for the drug to cure the infection. Metronidazole (500 mg twice daily for 7 days) continues to be highly efficacious in the treatment of bacterial vaginosis. Shorter oral treatment regimens that use single 2-g doses of metronidazole for 2-3 days appear promising but may be associated with higher relapse rates. Oral clindamycin (300 mg twice daily) or local 2% clindamycin cream (once daily for 7 days) also may be effective. Metronidazole intravaginal sponges (250-1,000 mg) used for 3 days may also be effective in the treatment of bacterial vaginosis.

• Authors: J G Lossick
• Journal: Reviews of infectious diseases (Rev Infect Dis) 1990 Jul-Aug Vol. 12 Suppl 6 Pg. S665-81 ISSN: 0162-0886 [Print] United States
• PMID: 2201078 (Publication Type: Journal Article, Review)

Chemical References

• Metronidazole

Topics

• Bacterial Infections (drug therapy)
• Female
• Humans
• Metronidazole (adverse effects, pharmacokinetics, therapeutic use)
• Microbial Sensitivity Tests
• Pregnancy
• Pregnancy Complications, Infectious (drug therapy)
• Sexual Partners
• Sexually Transmitted Diseases (drug therapy)
• Trichomonas Vaginitis (drug therapy)
• Vaginitis (drug therapy)