Synovial sarcoma of the tongue confirmed by molecular detection of the SYT-SSX2 fusion gene transcript.

Abstract

Involvement of the tongue by a synovial sarcoma (SS) is an extremely rare event; there have only been 13 cases previously reported. The authors present herein a case of monophasic SS arising in the tongue in a 32-year-old woman. The neoplasm expressed cytokeratins AE1-3, OSCAR, and EMA as well as Bcl-2 and TLE1. Molecular analysis indicated that the patient tested positive for the SYT/SS2 fusion transcript.

• Authors: Jaime Villaroel-Salinas, Jesús Campos-Martinez, Carlos Ortiz-Hidalgo
• Journal: International journal of surgical pathology (Int J Surg Pathol) Vol. 20 Issue 4 Pg. 386-9 (Aug 2012) ISSN: 1940-2465 [Electronic] United States
• PMID: 22007079 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biomarkers, Tumor
• Co-Repressor Proteins
• Keratin-3
• Mucin-1
• OSCAR protein, human
• Oncogene Proteins, Fusion
• Proto-Oncogene Proteins c-bcl-2
• Receptors, Cell Surface
• Repressor Proteins
• SYT-SSX fusion protein
• TLE1 protein, human

Topics

• Adult
• Biomarkers, Tumor (metabolism)
• Cell Proliferation
• Co-Repressor Proteins
• Female
• Humans
• Keratin-3 (metabolism)
• Mucin-1 (metabolism)
• Oncogene Proteins, Fusion (genetics, metabolism)
• Pathology, Molecular (methods)
• Proto-Oncogene Proteins c-bcl-2 (metabolism)
• Receptors, Cell Surface (metabolism)
• Repressor Proteins (metabolism)
• Reverse Transcriptase Polymerase Chain Reaction (methods)
• Sarcoma, Synovial (diagnosis, genetics, metabolism)
• Tongue (pathology, surgery)
• Tongue Neoplasms (diagnosis, genetics, metabolism)