Canomad presenting without ophthalmoplegia and responding to intravenous immunoglobulin.

Abstract

The acronym CANOMAD encompasses chronic ataxic neuropathy combined with ophthalmoplegia, M protein, cold agglutinins, and anti-disialosyl antibodies.Herein we describe 2 patients presenting with progressive ataxic neuropathy who only developed ophthalmoplegia after a significant delay post-presentation, which in 1 case had features indicative of brainstem dysfunction. Both patients were found to have an IgM paraprotein and anti-disialosyl antibodies. They responded to treatment with intravenous immunoglobulin, thus illustrating the importance of diagnosing this condition.

• Authors: Cheryl Kam, Michelle S Balaratnam, Alistair Purves, Kerry R Mills, Paul Riordan-Eva, Steve Pollock, Istvan Bodi, Neil A R Munro, David L H Bennett
• Journal: Muscle & nerve (Muscle Nerve) Vol. 44 Issue 5 Pg. 829-33 (Nov 2011) ISSN: 1097-4598 [Electronic] United States
• PMID: 22006700 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2011 Wiley Periodicals, Inc.

Chemical References

• Immunoglobulins, Intravenous

Topics

• Adult
• Aged
• Anemia, Hemolytic, Autoimmune (diagnosis, drug therapy, physiopathology)
• Ataxia (diagnosis, drug therapy, physiopathology)
• Diagnosis, Differential
• Female
• Humans
• Immunoglobulins, Intravenous (administration & dosage)
• Male
• Ophthalmoplegia (diagnosis, drug therapy, physiopathology)