[Levels of serum acylation-stimulating protein and C3 in children with primary nephrotic syndrome].

Abstract

OBJECTIVE:

To study serum acylation-stimulating protein (ASP) and complement 3 (C3) levels and their relationship with blood lipids in children with primary nephrotic syndrome (PNS).

METHODS:

Blood samples were obtained from 35 PNS children with proteinuria, 25 children with PNS at remission and 35 body mass index-matched healthy children (control group). Fasting serum ASP, C3, albumin and blood lipids were measured.

RESULTS:

The serum ASP levels in the proteinuria group (101 ± 22 nmol/L) were significantly higher than those in the remission group (32 ± 8 nmol/L) and the control group (33 ± 8 nmol/L) (P<0.01). Serum C3 levels were not significantly different among the three groups. The serum concentrations of total cholesterol, triglyceride, low density lipoprotein and apolipoprotein B increased, in contrast, serum albumin level decreased significantly in the proteinuria group when compared with the remission and the control groups. Serum ASP levels were positively correlated with serum C3 (r=0.661; P<0.05) and triglyceride levels (r=0.354; P<0.05), whereas serum C3 levels were not correlated with serum triglyceride levels (r=0.319, P>0.05).

CONCLUSIONS:

The increased serum ASP level may be associated with a complemental mechanism against hyperlipidemia in children with PNS.

• Authors: Jian-Jun Wang, Yue Huang, Chun Wu, Yu-Xia Xu, Yu-Shu Wei, Yao Zhao
• Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics (Zhongguo Dang Dai Er Ke Za Zhi) Vol. 13 Issue 10 Pg. 817-9 (Oct 2011) ISSN: 1008-8830 [Print] China
• PMID: 22000439 (Publication Type: English Abstract, Journal Article)

Chemical References

• C3 protein, human
• Complement C3
• Intercellular Signaling Peptides and Proteins
• Lipids
• Serum Albumin

Topics

• Child, Preschool
• Complement C3 (analysis)
• Female
• Humans
• Infant
• Intercellular Signaling Peptides and Proteins (blood)
• Lipids (blood)
• Male
• Nephrotic Syndrome (blood)
• Serum Albumin (analysis)