[The results of combined treatment patients with olfactory neuroblastoma in material of Cancer Center in Warsaw].

Abstract

UNLABELLED:

The results of combined treatment patients with olfactory neuroblastoma in material of Cancer Center in Warsaw

AIM:

The analysis of the results of combined treatment patients with olfactory neuroblastoma in material of Cancer Center in Warsaw.

MATERIAL:

Authors present material of 27 cases olfactory neuroblastoma treated in Cancer Center of Warsaw from 1965 to 2008. The median age was 44 years (range 10-74). The median observation was 72 months (range 2-235).The tumors were seen in 15 women and 12 men. According to Kadish staging there were one A, eight B, and seventeen C stage tumor. The patients in stage A and B was treated by surgery and radiotherapy (mean dose in whole material was 57.15 Gy range 44-70). Five patients in stage C was treated by surgery, radiotherapy and adjuvant chemotherapy. Five patients were treated by neoadjuvant chemotherapy and radiotherapy. Six patients underwent surgery and radiotherapy. One patient was died during adjuvant chemotherapy. One patient in stage B had local recurrence, one local recurrence and metastases and one had only metastases. In stage C 4 patients was died because of metastases, one had local recurrence and, 3 was died because of other reasons. Patients who was failed, underwent surgery, chemotherapy or radiotherapy, it was dependent of clinical situation.

RESULTS:

A complete regression was seen in 100% patients in early stages (A and B) and 82% patients in stage C. The 5-year local progression-free survival rate was 91% in early stages and 60% in stage C. The LPFS in whole group was 66.7%. The 5-year disease-free survival rate was 91% in early stages, 46% in stage C. The DSF rate in whole group was 44.4%. The 5-year overall survival rate was 80% in stages A and B, 41.2% in stage C. The OS in whole group was 55.6%. The 5-year survival rate was 20% for patients who had recurrence and/or metastases.

CONCLUSION:

A combination of surgery and radiotherapy appears to be adequate treatment for early stages (A and B) olfactory neuroblastoma. There are still no clear protocols of treatment patients in stage C.

• Authors: Andrzej Jarząbski, Dorota Kiprian, Zbigniew Szutkowski, Andrzej Kawecki, Wojciech Michalski
• Journal: Otolaryngologia polska = The Polish otolaryngology (Otolaryngol Pol) Vol. 65 Issue 5 Suppl Pg. 93-7 (Sep 2011) ISSN: 2300-8423 [Electronic] Poland
• Vernacular Title: Wyniki skojarzonego leczenia nerwiaka węchowego (olfactory neuroblastoma) w materiale Centrum Onkologii w Warszawie.
• PMID: 22000257 (Publication Type: English Abstract, Journal Article)
• Copyright: Copyright © 2011 Polish Otolaryngology Society. Published by Elsevier Urban & Partner (Poland). All rights reserved.

Chemical References

• Antineoplastic Agents

Topics

• Adolescent
• Adult
• Antineoplastic Agents (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Child
• Combined Modality Therapy
• Esthesioneuroblastoma, Olfactory (drug therapy, pathology, radiotherapy)
• Female
• Humans
• Male
• Neoplasm Staging
• Nose Neoplasms (drug therapy, pathology, radiotherapy)
• Poland
• Prognosis
• Radiotherapy, Adjuvant
• Retrospective Studies
• Survival Rate
• Treatment Outcome
• Young Adult