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[Exposure to nanoparticle-rich diesel exhaust affects hippocampal functions in mice].

Abstract
Epidemiological studies have indicated associations between day-to-day particulate air pollution and increased risks of various adverse health outcomes. Although an association between exposure to diesel exhaust particles (DEPs) and the development of pulmonary inflammation has been reported, there are limited reports on the neurotoxic effects of DEPs, particularly those of nanoparticle-rich diesel exhaust (NRDE). In this minireview, we highlighted the effects of NRDE which was generated in the National Institute for Environmental Studies, on hippocampus-dependent spatial learning ability and the expression of memory-function-related genes, neurotrophins, and proinflammatory cytokines in a mouse model.
AuthorsTin Tin Win-Shwe, Yuji Fujitani, Seishiro Hirano, Hidekazu Fujimaki
JournalNihon eiseigaku zasshi. Japanese journal of hygiene (Nihon Eiseigaku Zasshi) Vol. 66 Issue 4 Pg. 628-33 (Sep 2011) ISSN: 0021-5082 [Print] Japan
PMID21996758 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Particulate Matter
  • Vehicle Emissions
Topics
  • Animals
  • Hippocampus (drug effects)
  • Learning (drug effects)
  • Male
  • Memory (drug effects)
  • Mice
  • Nanoparticles (toxicity)
  • Particulate Matter (pharmacology)
  • Vehicle Emissions (toxicity)

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